Sjögren's syndrome is a chronic systemic autoimmune disease affecting from 0.2 to 3% of
the general population. The current treatment for Sjögren's syndrome is aimed at controlling …

Topical ocular drug delivery faces several challenges due to the eye's unique anatomy and
physiology. Physiological barriers, tear turnover, and blinking hinder the penetration of …

Purpose: The aim of this study was to develop and characterize a liposomal product
containing sirolimus to be administered subconjunctivally for the treatment of nonresponsive …

Atopic dermatitis (AD) is a chronic autoimmune inflammatory skin disorder which causes a
significant clinical problem due to its prevalence. The ongoing treatment for AD is aimed at …

Corticosteroids and macrolide immunomodulators such as tacrolimus are effective drugs for
the topical treatment of inflammatory eye diseases like allergic conjunctivitis or dry eye …

Eye drops are ophthalmic formulations routinely used to treat dry eye. However, the low
ocular bioavailability is an obvious drawback of eye drops owing to short ocular retention …

Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants
are drugs that can inhibit the body's immune response. Considering drug side effects such …

Glaucoma treatment with ocular medications requires overcoming the corneal barrier to drug
penetration. Liposomes have a great corneal penetration ability and affinity while suffering …

Topical route of administration is the most commonly used method for the treatment of
ophthalmic diseases. However, presence of several layers of permeation barriers starting …

Topical ophthalmic antibiotics show low efficacy due to the well-known physiological
defense mechanisms of the eye, which prevents the penetration of exogenous substances …