[HTML][HTML] Identification of a protein responsible for the synthesis of archaeal membrane-spanning GDGT lipids

Z Zeng, H Chen, H Yang, Y Chen, W Yang… - Nature …, 2022 - nature.com
Glycerol dibiphytanyl glycerol tetraethers (GDGTs) are archaeal monolayer membrane lipids
that can provide a competitive advantage in extreme environments. Here, we identify a …

[HTML][HTML] Discovery, structure and mechanism of a tetraether lipid synthase

CT Lloyd, DF Iwig, B Wang, M Cossu, WW Metcalf… - Nature, 2022 - nature.com
Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to
withstand extreme environmental conditions, such as high temperatures, high salinity, and …

GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean

Z Zeng, XL Liu, KR Farley, JH Wei… - Proceedings of the …, 2019 - National Acad Sciences
Glycerol dibiphytanyl glycerol tetraethers (GDGTs) are distinctive archaeal membrane-
spanning lipids with up to eight cyclopentane rings and/or one cyclohexane ring. The …

A re-evaluation of the archaeal membrane lipid biosynthetic pathway

L Villanueva, JSS Damsté, S Schouten - Nature Reviews Microbiology, 2014 - nature.com
Archaea produce unique membrane lipids in which isoprenoid alkyl chains are bound to
glycerol moieties via ether linkages. As cultured representatives of the Archaea have …

Widespread occurrence of structurally diverse tetraether membrane lipids: evidence for the ubiquitous presence of low-temperature relatives of hyperthermophiles

S Schouten, EC Hopmans… - Proceedings of the …, 2000 - National Acad Sciences
Isoprenoid glycerol dialkyl glycerol tetraethers (GDGTs) and branched glycerol dialkyl
diethers are main membrane constituents of cultured hyperthermophilic archaea and …

Archaeal and bacterial glycerol dialkyl glycerol tetraether lipids in hot springs of Yellowstone National Park

S Schouten, MTJ van der Meer… - Applied and …, 2007 - Am Soc Microbiol
Glycerol dialkyl glycerol tetraethers (GDGTs) are core membrane lipids originally thought to
be produced mainly by (hyper) thermophilic archaea. Environmental screening of low …

The production of diverse brGDGTs by an Acidobacterium providing a physiological basis for paleoclimate proxies

Y Chen, F Zheng, H Yang, W Yang, R Wu, X Liu… - … et Cosmochimica Acta, 2022 - Elsevier
Microbial lipid biomarkers preserved in geological archives can be used to explore past
climate changes. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are unique …

[HTML][HTML] Biosynthesis of archaeal membrane ether lipids

S Jain, A Caforio, AJM Driessen - Frontiers in microbiology, 2014 - frontiersin.org
A vital function of the cell membrane in all living organism is to maintain the membrane
permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in …

Phylogenomic analysis of lipid biosynthetic genes of Archaea shed light on the 'lipid divide'

L Villanueva, S Schouten… - Environmental …, 2017 - Wiley Online Library
The lipid membrane is one of the most characteristic traits distinguishing the three domains
of life. Membrane lipids of Bacteria and Eukarya are composed of fatty acids linked to …

Biosynthesis of archaebacterial ether lipids. Formation of ether linkages by prenyltransferases

D Zhang, CD Poulter - Journal of the American Chemical Society, 1993 - ACS Publications
Biosynthesis of (/?)-2, 3-di-0-phytanylglycerol (1), the core lipid of the membranes in the
strict anaerobe Metha-nobacterium thermoautotrophicum, was studied in cell-free …