BACKGROUND: Hemodialysis requires anticoagulation to prevent clotting of the
extracorporeal circuit. Systemic anticoagulation with heparin is contraindicated in patients at …

Background. Anticoagulation is a prerequisite for successful haemodialysis. Heparin and
low-molecular weight heparins are routinely used despite increased bleeding risk. Regional …

Background Recommended regular saline flushing presents clinical ineffectiveness for
hemodialysis (HD) patients at high risk of bleeding with heparin contraindication. Regional …

Evidence on the optimal anticoagulation regimen for hemodialysis in patients at high
bleeding risk is scarce. The HepZero study is the first large multinational study comparing …

Citrate has many characteristics of the ideal anticoagulant for hemodialysis. In addition to
immediate and complete anticoagulation in the dialysis circuit, citrate has important effects …

Background. Binding of polycationic unfractionated heparin onto the modified AN69
polyacrylonitrile membrane, whose surface electronegativity has been neutralized by …

Background Regional citrate anticoagulation (RCA) may be a valuable alternative to
systemic heparin anticoagulation during continuous venovenous hemodialysis (CVVH) …

Background: Regional anticoagulation with trisodium citrate is an effective form of
anticoagulation for continuous renal replacement therapy (CRRT) in patients at a high risk of …

Acute kidney injury requiring renal replacement therapy occurs in up to 10% of all intensive
care unit patients. Those who are hemodynamically unstable are often treated with …

Objective In this clinical trial, we aimed to compare three means of performing chronic
hemodialysis in patients with contra-indication to systemic heparinization. Methods This …