During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

The nuclear factor-kappaB (NF-κB) transcription factors have emerged as major regulators
of programmed cell death (PCD) whether via apoptosis or necrosis. In this context, NF-κB's …

The Rel/NF-κB transcription factors are key regulators of programmed cell death (PCD).
Their activity has significant physiological relevance for normal development and …

The transcription factor nuclear factor κB (NF-κB) is a pleiotropic protein complex that is
activated from a sequestered, cytoplasmic form by pro-inflammatory extracellular signals …

Nuclear factor-κB (NF-κB) is generally viewed as anti-apoptotic and oncogenic, leading to a
quest for its inhibitors. However, recent evidence suggests that in some situations NF-κB …

Abstract The REL/NF-κB/IκB superfamily of signal transducers and transcription factors are
paradigmatic of molecular mechanisms by which rapid responses in the immune system can …

Apoptosis is a physiological process critical for organ development, tissue homeostasis, and
elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can …

The most extensively studied function of NF-κB is its ability to promote cell survival through
induction of target genes, whose products inhibit various aspects of the apoptotic machinery …

Apoptosis: Activate NF- B or die? Page 1 R94 Dispatch Apoptosis: Activate NF- B or die? Vijay
R. Baichwal and Patrick A. Baeuerle Activation of the transcription factor NF- B has been linked …

The imbalance between proliferation and programmed cell death (apoptosis) is one of the
critical cellular events that lead to oncogenesis. While there is no doubt that uncontrolled cell …