Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure–activity relationship and molecular modelling simulations
In this protocol, a series of 3-benzyloxyflavone derivatives have been designed,
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …
Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors
The prime objective of this research work is to prepare readily soluble synthetic analogues
of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various …
of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various …
2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: synthesis, biological activity and molecular modeling
A series of 2-phenylbenzofurans compounds was designed, synthesized and evaluated as
cholinesterase inhibitors. The biological assay experiments showed that most of the …
cholinesterase inhibitors. The biological assay experiments showed that most of the …
Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, structure-activity relationship and molecular docking …
To explore new scaffolds for the treat of Alzheimer's disease appears to be an inspiring goal.
In this context, a series of varyingly substituted flavonols and 4-thioflavonols have been …
In this context, a series of varyingly substituted flavonols and 4-thioflavonols have been …
Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies
Flavonoids are one of the largest classes of plant secondary metabolites and are known to
possess a number of significant biological activities for human health. In this study, we …
possess a number of significant biological activities for human health. In this study, we …
Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies
Inhibition of high cholinesterase levels including acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives
Coumarins of synthetic or natural origins are an important chemical class exerting diverse
pharmacological activities. In the present study, 26 novel O-alkylcoumarin derivatives were …
pharmacological activities. In the present study, 26 novel O-alkylcoumarin derivatives were …
Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives
Background Many natural products, particularly phenolic compounds, have been reported to
have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase …
have a strong inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase …
[PDF][PDF] Coumarin derivatives as acetyl-and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study
MN Abu-Aisheh, A Al-Aboudi, MS Mustafa… - Heliyon, 2019 - cell.com
Alzheimer's disease is an irreversible and progressive brain disease that can cause
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …
[HTML][HTML] Synthesis, biological evaluation and molecular modeling studies of phthalazin-1 (2 H)-one derivatives as novel cholinesterase inhibitors
A new series of donepezil analogues based on the phthalazin-1 (2H)-one scaffold was
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …