Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

MD Larsen, M Lopez-Perez, EK Dickson… - Nature …, 2021 - nature.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …

Targets of antibodies against Plasmodium falciparum–infected erythrocytes in malaria immunity

JA Chan, KB Howell, L Reiling, R Ataide… - The Journal of …, 2012 - Am Soc Clin Investig
Plasmodium falciparum is the major cause of malaria globally and is transmitted by
mosquitoes. During parasitic development, P. falciparum–infected erythrocytes (P …

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

L Barfod, MB Dalgaard, ST Pleman… - Proceedings of the …, 2011 - National Acad Sciences
Plasmodium falciparum malaria is a major cause of mortality and severe morbidity. Its
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized …

L Stevenson, E Laursen, GJ Cowan, B Bandoh… - PLoS …, 2015 - journals.plos.org
Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected
erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte …

Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

JA Chan, FJI Fowkes, JG Beeson - Cellular and Molecular Life Sciences, 2014 - Springer
Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

Antibody Targets on the Surface of Plasmodium falciparum–Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children

JA Chan, MJ Boyle, KA Moore, L Reiling… - The Journal of …, 2019 - academic.oup.com
Abstract Background Sequestration of Plasmodium falciparum–infected erythrocytes (IEs) in
the microvasculature contributes to pathogenesis of severe malaria in children. This …

Investigating the function of Fc‐specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting

L Stevenson, P Huda, A Jeppesen… - Cellular …, 2015 - Wiley Online Library
Acquired protection from P lasmodium falciparum malaria takes years to develop, probably
reflecting the ability of the parasites to evade immunity. A recent example of this is the …

Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-γ

MC D'Ombrain, TS Voss, AG Maier, JA Pearce… - Cell host & …, 2007 - cell.com
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variable antigen
expressed by P. falciparum, the malarial parasite. PfEMP-1, present on the surface of …

Regulation of immune response by Plasmodium‐infected red blood cells

FM Ndungu, BC Urban, K Marsh… - Parasite …, 2005 - Wiley Online Library
During the asexual blood stage infection of the human malaria parasite, Plasmodium
falciparum, parasite‐derived proteins are inserted onto the surface of the host red blood cell …

Identification of residues in the Cμ4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

A Ghumra, JP Semblat, RS McIntosh… - The Journal of …, 2008 - journals.aai.org
The binding of nonspecific human IgM to the surface of infected erythrocytes is important in
rosetting, a major virulence factor in the pathogenesis of severe malaria due to Plasmodium …