Macrophages are mononuclear phagocytes which derive either from blood-borne
monocytes or reside as resident macrophages in peripheral (Kupffer cells of the liver …

The activation of P2X7 receptor (P2X7R) on M1 polarized macrophages induces the
assembly of the NLRP3 inflammasome leading to the release of pro-inflammatory cytokines …

Extracellular nucleotides are important mediators of activation, triggering various responses
through plasma membrane P2 and P1 receptors. P2 receptors are further subdivided into …

Abstract The P2X7 receptor (P2X7R) is a ligand-gated receptor belonging to the P2 receptor
family. It is distributed in various tissues of the human body and is involved in regulating the …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …

The human P2X7 receptor is a two‐transmembrane ionotropic receptor which has a
ubiquitous distribution and is most highly expressed on immune cells. In macrophages and …

Abstract P2X7 receptor (P2X7R), a distinct ligand-gated ion channel, is a member of
purinergic type 2 receptor family with ubiquitous expression in human body. Previous …

Introduction: The P2X7 receptor (P2X7R) has an important role in inflammation and
immunity, but until recently, clinical application has been limited by a lack of specific …

P2X receptors function as ATP-gated cation channels. The P2X7receptor subtype is
distinguished from other P2X family members by a very low affinity for extracellular ATP …