Pancreatic islets are the body's central rheostat that regulates glucose homeostasis through
the production of different hormones, including β cell-derived insulin. During obesity …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion
from pancreatic β‐cells. Inflammatory cytokines, including tumour necrosis factor‐α (TNF‐α) …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

The islet of Langerhans produces endocrine hormones to regulate glucose homeostasis.
The normal function of the islet relies on the homeostatic regulations of cellular composition …

In the past decade, islet inflammation has emerged as a contributor to the loss of functional β
cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that …

Chronic systemic inflammation is a hallmark feature of obesity and type 2 diabetes. Both
resident and recruited islet macrophages contribute to the proinflammatory milieu of the …

Evidence in support of the concept of local pancreatic islet inflammation as a mechanism of
β cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 …

Impaired function and reduced mass of pancreatic islet β-cells are two hallmarks of type 2
diabetes (T2D)(1, 2). However, clinical onset of T2D does not occur until β-cells fail to …