Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts
SR Shaikh - The Journal of nutritional biochemistry, 2012 - Elsevier
N-3 polyunsaturated fatty acids (PUFAs) from fish oil exert their functional effects by targeting
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …
[HTML][HTML] Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains
JA Williams, SE Batten, M Harris, BD Rockett… - Biophysical journal, 2012 - cell.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly
recognized to have potential benefits for treating many human afflictions. Despite the …
recognized to have potential benefits for treating many human afflictions. Despite the …
[HTML][HTML] How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems
Marine long chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic (EPA) and
docosahexaenoic acid (DHA), are bioactive molecules with clinical applications for the …
docosahexaenoic acid (DHA), are bioactive molecules with clinical applications for the …
n− 3 PUFA and membrane microdomains: a new frontier in bioactive lipid research
DWL Ma, J Seo, KC Switzer, YY Fan… - The Journal of nutritional …, 2004 - Elsevier
In recent years, our understanding of the plasma membrane has changed considerably as
our knowledge of lipid microdomains has expanded. Lipid microdomains include structures …
our knowledge of lipid microdomains has expanded. Lipid microdomains include structures …
[HTML][HTML] Docosahexaenoic acid alters the size and distribution of cell surface microdomains
RS Chapkin, N Wang, YY Fan, JR Lupton… - Biochimica et Biophysica …, 2008 - Elsevier
We recently generated nutritional data suggesting that chemoprotective dietary n-3
polyunsaturated fatty acids (n-3 PUFA) are capable of displacing acylated proteins from lipid …
polyunsaturated fatty acids (n-3 PUFA) are capable of displacing acylated proteins from lipid …
[HTML][HTML] All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA
X Leng, JJ Kinnun, AT Cavazos, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Eicosapentaenoic (EPA, 20: 5), docosahexaenoic (DHA, 22: 6) and
docosapentaenoic (DPA, 22: 5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) …
docosapentaenoic (DPA, 22: 5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) …
[HTML][HTML] Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts
YY Fan, DN McMurray, LH Ly, RS Chapkin - The Journal of nutrition, 2003 - Elsevier
In vitro evidence indicates that (n-3) polyunsaturated fatty acids (PUFA) suppress T-cell
activation in part by displacing proteins from lipid rafts, specialized regions within the plasma …
activation in part by displacing proteins from lipid rafts, specialized regions within the plasma …
n− 3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization
SR Shaikh, CA Jolly, RS Chapkin - Molecular aspects of medicine, 2012 - Elsevier
Fish oil, enriched in bioactive n− 3 polyunsaturated fatty acids (PUFA), has therapeutic value
for the treatment of inflammation-associated disorders. The effects of n− 3 PUFAs are …
for the treatment of inflammation-associated disorders. The effects of n− 3 PUFAs are …
[HTML][HTML] Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation
SR Wassall, X Leng, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Docosahexaenoic acid (DHA, 22: 6) is an n− 3 polyunsaturated fatty acid (n− 3
PUFA) that influences immunological, metabolic, and neurological responses through …
PUFA) that influences immunological, metabolic, and neurological responses through …
Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids
HF Turk, RS Chapkin - Prostaglandins, Leukotrienes and Essential Fatty …, 2013 - Elsevier
Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has been shown to
play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and …
play a role in prevention of colon cancer. The effects of n-3 PUFA are pleiotropic and …