Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection

SR Shaikh, M Edidin - Chemistry and Physics of Lipids, 2008 - Elsevier
Polyunsaturated fatty acids (PUFAs), notably of the n-3 series, have immunosuppressive
effects which make these molecules candidates for treating inflammatory symptoms …

Polyunsaturated fatty acids, membrane function and metabolic diseases such as diabetes and obesity

LH Storlien, AJ Hulbert, PL Else - Current Opinion in Clinical …, 1998 - journals.lww.com
Lipids play an extraordinary range of roles in normal and deranged metabolism. In diabetes
and obesity, lipids have often been seen just as impacting on the energy balance equation …

[HTML][HTML] DHA modifies the size and composition of raftlike domains: a solid-state 2H NMR study

JJ Kinnun, R Bittman, SR Shaikh, SR Wassall - Biophysical journal, 2018 - cell.com
Docosahexaenoic acid is an omega-3 polyunsaturated fatty acid that relieves the symptoms
of a wide variety of chronic inflammatory disorders. The structural mechanism is not yet …

[HTML][HTML] Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

T Hashidate-Yoshida, T Harayama, D Hishikawa… - Elife, 2015 - elifesciences.org
Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of
membranes, but it is unclear which biological processes are influenced by their regulation …

The nutritional and clinical significance of lipid rafts

P Yaqoob, SR Shaikh - Current Opinion in Clinical Nutrition & …, 2010 - journals.lww.com
In-vitro and animal studies show that n-3 PUFAs, cholesterol, and gangliosides modulate the
structure and composition of lipid rafts, potentially influencing a wide range of biological …

Omega 3-fatty acids: health benefits and cellular mechanisms of action

RA Siddiqui, SR Shaikh, LA Sech… - Mini reviews in …, 2004 - ingentaconnect.com
Epidemiological evidence has established that ingestion of long-chain polyunsaturated
omega-3 fatty acids (ω-3 PUFAs), abundant in fish oils, have profound effects on many …

[HTML][HTML] n-3 polyunsaturated fatty acids suppress CD4+ T cell proliferation by altering phosphatidylinositol-(4, 5)-bisphosphate [PI (4, 5) P2] organization

TY Hou, R Barhoumi, YY Fan, GM Rivera… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The mechanisms by which n-3 polyunsaturated fatty acids (n-3 PUFA), abundant in fish oil,
exert their anti-inflammatory effects have not been rigorously defined. We have previously …

Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages

JE McLaren, DR Michael, IA Guschina, JL Harwood… - Lipids, 2011 - Springer
There is evidence that long chain n-3 PUFA (such as from fish oils) provide atheroprotection
through, in part, changes in macrophage function although it has not been fully determined …

Omega-3 fatty acids, membrane remodeling and cancer prevention

NR Fuentes, E Kim, YY Fan, RS Chapkin - Molecular aspects of medicine, 2018 - Elsevier
Proteins are often credited as the macromolecule responsible for performing critical cellular
functions, however lipids have recently garnered more attention as our understanding of …

Sea cucumber and blue mussel: new sources of phospholipid enriched omega-3 fatty acids with a potential role in 3T3-L1 adipocyte metabolism

H Vaidya, SK Cheema - Food & function, 2014 - pubs.rsc.org
Omega (n)-3 polyunsaturated fatty acids (PUFA), namely docosahexaenoic acid (DHA) and
eicosapentaenoic acid (EPA), are known to reduce the risk of insulin resistance and …