Bone healing is a complex physiological process initiated by early regulation of the
inflammatory immunity and entails multiple events including angiogenesis, osteogenic …

The periosteum plays an important role in the regeneration of critical-size bone defects, with
functions of recruiting multiple cells, accelerating vascular network reconstruction, and …

Periosteum plays the pivotal role in neomineralization, vascularization and protection during
bone tissue regeneration. However, many artificial periosteum focused only on protection …

Allografts remain the clinical “gold standard” for treatment of critical sized bone defects
despite minimal engraftment and∼ 60% long-term failure rates. Therefore, the development …

The bone immune microenvironment (BIM) regulates bone regeneration and affects the
prognosis of fractures. However, there is currently no effective strategy that can precisely …

Periosteum plays a pivotal role in vascularization, ossification and remodeling during the
healing process of bone injury. However, there are few studies focused on the construction …

Recently, biomaterials with immune‐regulating properties have emerged as crucial new
platforms for bone tissue engineering. Inducing macrophages to differentiate into M2 …

Bone repair in patients with osteoporosis remains a big challenge because their injury sites
are often accompanied by an abnormal level of inflammation and reactive oxygen species …

The immune response of the host towards foreign body, especially in the form of giant cell
reaction against the implanted materials, is a vital factor for determining the repair outcome …

The objective of this work was to investigate the effects of macroporous hydrogel
architecture on the osteogenic signal expression and differentiation of human mesenchymal …