Background Scleroderma is a clinically heterogeneous disease with a complex phenotype.
The disease is characterized by vascular dysfunction, tissue fibrosis, internal organ …

Objective To examine the heterogeneity of global transcriptome patterns in systemic
sclerosis (SSc) skin in a large sample of patients with SSc and control subjects. Methods …

Objective To determine whether biopsy specimens obtained from systemic sclerosis (SSc)
lesions show a distinctive gene profile, whether that gene profile is maintained in fibroblasts …

We used DNA microarrays representing> 12,000 human genes to characterize gene
expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis …

Systemic sclerosis is a complex disease with widespread skin fibrosis and variable visceral
organ involvement. Since transforming growth factor-β (TGFβ) has been implicated in driving …

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four
'intrinsic'subsets of disease (fibroproliferative, inflammatory, limited, and normal-like), each …

The molecular mechanisms governing skin fibrosis in murine sclerodermatous graft-versus-
host disease (Scl GVHD) are not known. We used Affymetrix DNA microarrays representing> …

Systemic sclerosis (SSc) is a rare systemic autoimmune disease characterized by skin and
organ fibrosis. The pathogenesis of SSc and its progression are poorly understood. The SSc …

Objective High‐throughput gene expression profiling of tissue samples from patients with
systemic sclerosis (SS c) has identified 4 “intrinsic” gene expression subsets: inflammatory …

Skin biopsy gene expression was analyzed by DNA microarray from 13 diffuse cutaneous
systemic sclerosis (dSSc) patients enrolled in an open-label study of rituximab, 9 dSSc …