Newborn mice and piglets exhibit natural heart regeneration after myocardial infarction (MI).
Discovering other mammals with this ability would provide evidence that neonatal cardiac …

Myocardial infarction induced by coronary artery ligation has been used in many animal
models as a tool to study the mechanisms of cardiac repair and regeneration, and to define …

Rationale: Cardiac remodeling and subsequent heart failure remain critical issues after
myocardial infarction despite improved treatment and reperfusion strategies. Recently …

Cardiac remodeling and subsequent heart failure remain critical issues after myocardial
infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac …

Heart regeneration remains a critical question in current basic research and clinical practice.
The adult mammalian heart exhibits a very limited regeneration capacity. In contrast, adult …

Cardiac regeneration is one of the prime visions in cardiovascular research. The mouse
neonatal apical resection and left anterior descending artery (LAD) ligation model …

Although amphibian and fish models of heart regeneration have existed for decades, a
mammalian equivalent has long remained elusive. Our discovery of a brief postnatal window …

Background: The adult mammalian heart has limited ability to repair itself after injury.
Zebrafish, newts, and neonatal mice can regenerate cardiac tissue, largely by cardiac …

Background: Rodent hearts can regenerate myocardium lost to apical resection or
myocardial infarction for up to 7 days after birth, but whether a similar window for myocardial …

Background In adults, myocardial infarction (MI) results in a brisk inflammatory response,
myocardium loss, and scar formation. We have recently reported the first mammalian large …