Granzyme B is a caspase-like serine protease that is released by cytotoxic lymphocytes to
kill virus-infected and tumor cells. Major recent advances in our understanding of granzyme …

Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …

Granzymes are serine proteases mainly found in cytotoxic lymphocytes. The most-studied
member of this group is granzyme B, which is a potent cytotoxin that has set the paradigm …

Granzyme B is critical to the ability of natural killer cells and cytotoxic T lymphocytes to
induce efficient cell death of virally infected or tumor cell targets. Although granzyme B can …

Granzyme B is an important mediator of cytotoxic lymphocyte granule-induced death of
target cells, accomplishing this through cleavage of Bid and cleavage and activation of …

Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-
infected and tumor cells. In humans, five different granzymes (ie GrA, GrB, GrH, GrK, and …

The granzyme B-induced cell death has been traditionally viewed as a primary mechanism
that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate …

The cytotoxic granzyme B (GrB)/perforin pathway has been traditionally viewed as a primary
mechanism that is used by cytotoxic lymphocytes to eliminate allogeneic, virally infected …

The granzymes are cell death–inducing enzymes, stored in the cytotoxic granules of
cytotoxic T lymphocytes and natural killer cells, that are released during granule exocytosis …

Granzyme H (GzmH) belongs to a family of 5 human serine proteases that are expressed by
cytotoxic immune effector cells. Although GzmH is most closely related to the caspase …