Introduction Long-term daily administration of phosphodiesterase type 5 (PDE5) inhibitors in
the rat prevents or reverses corporal veno-occlusive dysfunction (CVOD) and smooth …

Introduction Radical prostatectomy (RP) is associated with erectile dysfunction (ED). A
single, placebo-controlled, human study has assessed the effects of regular sildenafil use …

Introduction Novel effective therapeutic strategies are necessary for treating erectile
dysfunction secondary to cavernous nerve injury (CNI). Aim To functionally evaluate the …

It was recently reported in the rat that vardenafil given in a continuous long-term manner was
successful in preventing smooth muscle fibrosis in the penile corpora cavernosa and …

Introduction It has been shown that phosphodiesterase type 5 (PDE5) inhibitors preserve
smooth muscle (SM) content and ameliorate the fibrotic degeneration normally seen in the …

Aging-related erectile dysfunction is characterized by a loss of smooth muscle cells (SMCs)
and fibrosis in the corpora cavernosa, and functionally by corporal veno-occlusive …

OBJECTIVE: To prevent cavernous nerve injury and corpus cavernosum apoptosis-induced
erectile dysfunction (ED) after prostatectomy surgery, we investigated whether oral …

Introduction With the advent of genetically engineered mice, it seems important to develop a
mouse model of cavernous nerve injury (CNI). Aim To establish a mouse model of CNI …

Introduction Radical prostatectomy is the treatment of choice for prostate cancer patients.
Despite the introduction of nerve-sparing surgical techniques, its success is not entirely …

Introduction We evaluated the potential preventive effects and mechanisms of intravenously
preloaded mesenchymal stem cells (MSCs) for erectile dysfunction (ED) in a cavernous …