Though most colorectal cancers show allelic losses, a subset of colorectal cancers
(microsatellite instability or MSI-positive cancers) develop numerous small insertion and …

Background & Aims: The p53 and BAX genes have been linked to apoptosis. p53 was not
frequently found to be mutated in colorectal carcinomas with a microsatellite mutator …

Disruption of the DNA mismatch repair system, characterized by microsatellite instability
(MI), plays an important role in the course of human carcinogenesis by increasing the rate of …

Half of colorectal tumors with microsatellite instability contain frameshift mutations in the (G)
8 tract of bax, a major apoptosis effector, but their functional significance remains unclear …

Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic
instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ …

A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer
of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene …

BAX gene mutations occur in approximately 50% of RER+ colorectal cancers. To determine
the role of these mutations in tumour progression we analysed multiple different tumour sites …

Bcl-2 is known to inhibit apoptosis and is thought to play a role in colorectal tumour
development. Studies of the promoter region of bcl-2 have indicated the presence of a p53 …

An exacerbated genomic instability characterizes hereditary and sporadic gastrointestinal
cancer of the microsatellite mutator phenotype (MMP), generating somatic frameshift …

Recent progress in the field of molecular biology has allowed us to identify at least two
different molecular mechanisms implicated in colorectal carcinogenesis (CRC) …