Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia but has no effective
treatment. A comprehensive investigation of cell type-specific responses and cellular …
treatment. A comprehensive investigation of cell type-specific responses and cellular …
Endothelial cells are heterogeneous in different brain regions and are dramatically altered in alzheimer's disease
Vascular endothelial cells play an important role in maintaining brain health, but their
contribution to Alzheimer's disease (AD) is obscured by limited understanding of the cellular …
contribution to Alzheimer's disease (AD) is obscured by limited understanding of the cellular …
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
The molecular signatures of cells in the brain have been revealed in unprecedented detail,
yet the ageing-associated genome-wide expression changes that may contribute to …
yet the ageing-associated genome-wide expression changes that may contribute to …
Cell type-specific potential pathogenic genes and functional pathways in Alzheimer's Disease
XL Wang, L Li - BMC neurology, 2021 - Springer
Background Alzheimer's disease (AD) is a pervasive age-related and highly heritable
neurodegenerative disorder but has no effective therapy. The complex cellular …
neurodegenerative disorder but has no effective therapy. The complex cellular …
Role of neuron and glia in Alzheimer's disease and associated vascular dysfunction
S Bandyopadhyay - Frontiers in aging neuroscience, 2021 - frontiersin.org
Amyloidogenicity and vascular dysfunction are the key players in the pathogenesis of
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …
Alzheimer's disease (AD), involving dysregulated cellular interactions. An intricate balance …
Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease
Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …
that occur in specific cell types have not been fully characterized. Here, we profile single …
Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression
Alzheimer's disease is the most common neurological disease worldwide. Unfortunately,
there are currently no effective treatment methods nor early detection methods. Furthermore …
there are currently no effective treatment methods nor early detection methods. Furthermore …
Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
MD Sweeney, AP Sagare… - Journal of Cerebral …, 2015 - journals.sagepub.com
Alzheimer's disease (AD) is the most common form of age-related dementias. In addition to
genetics, environment, and lifestyle, growing evidence supports vascular contributions to …
genetics, environment, and lifestyle, growing evidence supports vascular contributions to …
[HTML][HTML] Neural stem cell therapy for neurovascular injury in Alzheimer's disease
AC Boese, MH Hamblin, JP Lee - Experimental neurology, 2020 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
progressive neurodegeneration leading to severe cognitive decline and eventual death. AD …
progressive neurodegeneration leading to severe cognitive decline and eventual death. AD …
Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain's major cell types and are responsible for maintaining
neuronal homeostasis via regulating the extracellular environment, providing metabolic …
neuronal homeostasis via regulating the extracellular environment, providing metabolic …