Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery

S Kaur, P Sohnen, S Swamynathan, Y Du, EM Espana… - The Ocular Surface, 2023 - Elsevier
The structural and functional integrity of the ocular surface, a continuous epithelial structure
comprised of the cornea, the conjunctiva, and the ductal surface of the lacrimal as well as …

The ocular surface epithelial barrier and other mechanisms of mucosal protection: from allergy to infectious diseases

F Mantelli, J Mauris, P Argüeso - Current opinion in allergy and …, 2013 - journals.lww.com
The traditional model of intercellular junctions protecting the ocular surface epithelia has
recently been expanded to include an additional glycan shield that lines apical membranes …

Barrier function in the ocular surface: from conventional paradigms to new opportunities

YY Leong, L Tong - The ocular surface, 2015 - Elsevier
By providing a physical and immunological barrier, the ocular surface serves the important
function of protecting the vision apparatus. The barrier function keeps the cornea relatively …

Interfacial phenomena and the ocular surface

B Yañez-Soto, MJ Mannis, IR Schwab, JY Li… - The ocular …, 2014 - Elsevier
Ocular surface disorders, such as dry eye disease, ocular rosacea, and allergic
conjunctivitis, are a heterogeneous group of diseases that require an interdisciplinary …

Epithelial barrier dysfunction in ocular allergy

N Singh, Y Diebold, SK Sahu, A Leonardi - Allergy, 2022 - Wiley Online Library
The epithelial barrier is the first line of defense that forms a protective barrier against
pathogens, pollutants, and allergens. Epithelial barrier dysfunction has been recently …

Host-defense mechanism of the ocular surfaces

RA Sack, I Nunes, A Beaton, C Morris - Bioscience reports, 2001 - portlandpress.com
The defense of the ocular surfaces presents an unique challenge in that not only must
integrity be maintained against microbial, inflammatory and physical assault, but it must be …

[HTML][HTML] The ocular surface: the challenge to enable and protect vision: the Friedenwald lecture

IK Gipson - Investigative ophthalmology & visual science, 2007 - iovs.arvojournals.org
The surface of the eye is an extraordinary and vital component of vision. The smooth, wet
surface of the cornea is the major refractive surface of the visual system, which, along with …

[HTML][HTML] Ocular surface as barrier of innate immunity

R Bolaños-Jiménez, A Navas… - The open …, 2015 - ncbi.nlm.nih.gov
Sight is one of the most important senses that human beings possess. The ocular system is
a complex structure equipped with mechanisms that prevent or limit damage caused by …

Ocular barriers

H Nettey, Y Darko, OA Bamiro, RT Addo - Ocular drug delivery: advances …, 2016 - Springer
Drugs for ocular administration are administered topically and their absorption is limited by
different barriers known as ocular barriers. These barriers are located in different areas of …

Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease

S Barabino, Y Chen, S Chauhan, R Dana - Progress in retinal and eye …, 2012 - Elsevier
The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands
work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the …