[HTML][HTML] Immunology of SARS-CoV-2 infection in children

J Chou, PG Thomas, AG Randolph - Nature immunology, 2022 - nature.com
Children and adolescents exhibit a broad range of clinical outcomes from SARS-CoV-2
infection, with the majority having minimal to mild symptoms. Additionally, some succumb to …

[HTML][HTML] Humoral signatures of protective and pathological SARS-CoV-2 infection in children

YC Bartsch, C Wang, T Zohar, S Fischinger, C Atyeo… - Nature medicine, 2021 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to
spread relentlessly, associated with a high frequency of respiratory failure and mortality …

Insight into the pediatric and adult dichotomy of COVID‐19: age‐related differences in the immune response to SARS‐CoV‐2 infection

A Fialkowski, Y Gernez, P Arya… - Pediatric …, 2020 - Wiley Online Library
The difference in morbidity and mortality between adult and pediatric coronavirus disease
2019 infections is dramatic. Understanding pediatric‐specific acute and delayed immune …

[HTML][HTML] Lessons learned: new insights on the role of cytokines in COVID-19

M Buszko, A Nita-Lazar, JH Park, PL Schwartzberg… - Nature …, 2021 - nature.com
In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and
Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of …

[HTML][HTML] Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C)

CN Gruber, RS Patel, R Trachtman, L Lepow, F Amanat… - Cell, 2020 - cell.com
Initially, children were thought to be spared from disease caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel …

[HTML][HTML] Understanding COVID-19 in children: immune determinants and post-infection conditions

GA Rotulo, P Palma - Pediatric research, 2023 - nature.com
Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

LA Vella, JR Giles, AE Baxter, DA Oldridge… - Science …, 2021 - science.org
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …

Immune response to SARS-CoV-2 in children: A review of the current knowledge

F Filippatos, EB Tatsi, A Michos - Pediatric Investigation, 2021 - mednexus.org
Host immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
especially in children, are still under investigation. Children with coronavirus disease 2019 …

SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19

K Rybkina, JN Bell, MC Bradley, T Wohlbold… - Journal of Experimental …, 2023 - rupress.org
SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare
cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) …

[HTML][HTML] Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

K Sacco, R Castagnoli, S Vakkilainen, C Liu… - Nature medicine, 2022 - nature.com
Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …