An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite

GYS Delgado, M Navarro - Coordination Chemistry Reviews, 2024 - Elsevier
Malaria is one of the oldest and deadliest parasitic diseases globally, and it still poses a
global health issue today because of the emergence of new strains resistant to the first-line …

Gold complexes as potential anti-parasitic agents

M Navarro - Coordination Chemistry Reviews, 2009 - Elsevier
The medical uses of gold have a long history; rheumatoid arthritis is currently treated with
gold-based drugs and there is increasing interest in the application of gold complexes as …

Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure

BĐ Glišić, MI Djuran - Dalton Transactions, 2014 - pubs.rsc.org
Interest in antimicrobial gold complexes originated from the work of Robert Koch at the end
of 19th century, who demonstrated that potassium dicyanidoaurate (I), K [Au (CN) 2], showed …

Hybrid gold (I) NHC-artemether complexes to target falciparum malaria parasites

M Ouji, G Barnoin, Á Fernández Álvarez, JM Augereau… - Molecules, 2020 - mdpi.com
The emergence of Plasmodium falciparum parasites, responsible for malaria disease,
resistant to antiplasmodial drugs including the artemisinins, represents a major threat to …

Gold(i) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development

A Ssemaganda, LM Low, KR Verhoeft, M Wambuzi… - Metallomics, 2018 - academic.oup.com
Here, the anti-malarial activity of two gold (i) phosphine compounds auranofin and [Au
(d2pype) 2] Cl (where d2pype is 1, 2-bis (di-2-pyridylphosphino) ethane), were examined to …

[HTML][HTML] Gold (I) complexes bearing phosphole ligands: Synthesis and antimalarial activity

K Fourmy, M Gouygou… - Comptes …, 2017 - comptes-rendus.academie-sciences …
A series of gold (I)-monophosphole complexes have been synthesized and characterized.
The introduction of a nitrogen moiety in the complex structure was envisioned either by …

Antiplasmodial activities of gold (I) complexes involving functionalized N-heterocyclic carbenes

C Hemmert, AP Ramadani, L Boselli, AF Alvarez… - Bioorganic & medicinal …, 2016 - Elsevier
A series of twenty five molecules, including imidazolium salts functionalized by N-, O-or S-
containing groups and their corresponding cationic, neutral or anionic gold (I) complexes …

Biological activity of gold compounds against viruses and parasitosis: a systematic review

C Fonseca, M Aureliano - BioChem, 2022 - mdpi.com
In this contribution, we provide an overview of gold compound applications against viruses
or parasites during recent years. The special properties of gold have been the subject of …

A “Golden Age” for the discovery of new antileishmanial agents: current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione …

LB Rosa, RL Aires, LS Oliveira, JV Fontes… - …, 2021 - Wiley Online Library
Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious
public health issue. The current therapeutic options have several disadvantages that make …

[HTML][HTML] A hybrid of amodiaquine and primaquine linked by gold (I) Is a multistage antimalarial agent targeting heme detoxification and thiol redox homeostasis

CDS Pereira, HC Quadros, SY Aboagye… - …, 2022 - ncbi.nlm.nih.gov
Hybrid-based drugs linked through a transition metal constitute an emerging concept for
Plasmodium intervention. To advance the drug design concept and enhance the therapeutic …