[HTML][HTML] Genome-wide DNA methylation profiling of articular cartilage reveals significant epigenetic alterations in Kashin-Beck disease and osteoarthritis
Objective To determine genome-wide DNA methylation profiles of knee cartilage from
patients with Kashin-Beck disease (KBD) and osteoarthritis (OA). Method Knee cartilage …
patients with Kashin-Beck disease (KBD) and osteoarthritis (OA). Method Knee cartilage …
Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary …
Abstract Background Kashin-Beck disease (KBD) is an endemic osteochondropathy of
unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar …
unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar …
Integrative analysis of genome-wide association studies and DNA methylation profile identified genetic control genes of DNA methylation for kashin-beck disease
P Li, C Wu, X Guo, Y Wen, L Liu, X Liang, Y Du… - Cartilage, 2021 - journals.sagepub.com
Objective Epigenetic modifications of DNA are regarded as a crucial factor for understanding
the molecular basis of complex phenotypes. This study aims to uncover insight into the …
the molecular basis of complex phenotypes. This study aims to uncover insight into the …
Genome-Wide Differentially Methylated Region Analysis to Reveal Epigenetic Differences of Articular Cartilage in Kashin–Beck Disease and Osteoarthritis
Y Fan, D Gao, Y Zhang, J Zhu, F Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
Kashin–Beck disease (KBD) is a degenerative osteoarticular disorder, and displays the
significant differences with osteoarthritis (OA) regarding the etiology and molecular changes …
significant differences with osteoarthritis (OA) regarding the etiology and molecular changes …
Exploring genome-wide DNA methylation profiles altered in Kashin-Beck disease using Infinium human methylation 450 bead chips
XW Shi, BH Shi, AL Lyu, F Zhang, TT Zhou… - Biomedical and …, 2016 - Elsevier
To understand how differentially methylated genes (DMGs) might affect the pathogenesis of
Kashin-Beck disease (KBD). Genome-wide methylation profiling of whole blood from 12 …
Kashin-Beck disease (KBD). Genome-wide methylation profiling of whole blood from 12 …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …
E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
Analysis of methylation datasets identified significantly changed genes and functional pathways in osteoarthritis
B Han, Z Zheng, J Ren, W Qiu, X Li - Clinical Rheumatology, 2019 - Springer
Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …
Analysis of mRNA expression and DNA methylation datasets according to the genomic distribution of CpG sites in osteoarthritis
P Yi, X Xu, J Yao, B Qiu - Frontiers in Genetics, 2021 - frontiersin.org
Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …
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