[HTML][HTML] Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank
Genome-wide association studies using genotype data have had limited success in the
identification of variants associated with major depressive disorder (MDD). Haplotype data …
identification of variants associated with major depressive disorder (MDD). Haplotype data …
[HTML][HTML] Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank
Few replicable genetic associations for Major Depressive Disorder (MDD) have been
identified. Recent studies of MDD have identified common risk variants by using a broader …
identified. Recent studies of MDD have identified common risk variants by using a broader …
[HTML][HTML] Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia
Genetic studies in psychiatry have primarily focused on the effects of common genetic
variants, but few have investigated the role of rare genetic variants, particularly for major …
variants, but few have investigated the role of rare genetic variants, particularly for major …
Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies
To identify genetic risk loci for major depressive disorder (MDD), two broad study design
approaches have been applied:(1) to maximize sample size by combining data from …
approaches have been applied:(1) to maximize sample size by combining data from …
Genetic heterogeneity in self-reported depressive symptoms identified through genetic analyses of the PHQ-9
BackgroundDepression is a clinically heterogeneous disorder. Previous large-scale genetic
studies of depression have explored genetic risk factors of depression case–control status or …
studies of depression have explored genetic risk factors of depression case–control status or …
Multiple measures of depression to enhance validity of major depressive disorder in the UK Biobank
BackgroundThe UK Biobank contains data with varying degrees of reliability and
completeness for assessing depression. A third of participants completed a Mental Health …
completeness for assessing depression. A third of participants completed a Mental Health …
Genome-wide association study of major recurrent depression in the UK population
Objective Studies of major depression in twins and families have shown moderate to high
heritability, but extensive molecular studies have failed to identify susceptibility genes …
heritability, but extensive molecular studies have failed to identify susceptibility genes …
A genome-wide significant linkage for severe depression on chromosome 3: the depression network study
Objective: The purpose of this study was to find loci for major depression via linkage
analysis of a large sibling pair sample. Method: The authors conducted a genome-wide …
analysis of a large sibling pair sample. Method: The authors conducted a genome-wide …
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder
Y Liu, DH Blackwood, S Caesar, EJC de Geus… - Molecular …, 2011 - nature.com
Substantial indirect evidence suggests overlap between bipolar disorder (BIP) and major
depressive disorder (MDD). BIP and MDD have in common major depressive episodes with …
depressive disorder (MDD). BIP and MDD have in common major depressive episodes with …
Investigating genetic heterogeneity in major depression through item-level genetic analyses of the PHQ-9
Abstract Background Major Depressive Disorder (MDD) is a clinically heterogeneous
disorder. Previous large-scale genetic studies of MDD have explored genetic risk factors of …
disorder. Previous large-scale genetic studies of MDD have explored genetic risk factors of …