[HTML][HTML] Defining the role of the MHC in autoimmunity: a review and pooled analysis
MMA Fernando, CR Stevens, EC Walsh… - PLoS …, 2008 - journals.plos.org
The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune …
in the human genome because of the association of variants at this locus with autoimmune …
[HTML][HTML] The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
Human MHC architecture and evolution: implications for disease association studies
JA Traherne - International journal of immunogenetics, 2008 - Wiley Online Library
Major histocompatibility complex (MHC) variation is a key determinant of susceptibility and
resistance to a large number of infectious, autoimmune and other diseases. Identification of …
resistance to a large number of infectious, autoimmune and other diseases. Identification of …
Major histocompatibility complex genomics and human disease
J Trowsdale, JC Knight - Annual review of genomics and human …, 2013 - annualreviews.org
Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …
histocompatibility complex (MHC) have been extremely successful in picking up many …
Gene map of the extended human MHC
R Horton, L Wilming, V Rand, RC Lovering… - Nature Reviews …, 2004 - nature.com
The major histocompatibility complex (MHC) is the most important region in the vertebrate
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …
[HTML][HTML] A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms
MM Miretti, EC Walsh, X Ke, M Delgado… - The American Journal of …, 2005 - cell.com
Autoimmune, inflammatory, and infectious diseases present a major burden to human health
and are frequently associated with loci in the human major histocompatibility complex …
and are frequently associated with loci in the human major histocompatibility complex …
[HTML][HTML] An integrated haplotype map of the human major histocompatibility complex
EC Walsh, KA Mather, SF Schaffner, L Farwell… - The American Journal of …, 2003 - cell.com
Numerous studies have clearly indicated a role for the major histocompatibility complex
(MHC) in susceptibility to autoimmune diseases. Such studies have focused on the genetic …
(MHC) in susceptibility to autoimmune diseases. Such studies have focused on the genetic …
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
International MHC and Autoimmunity … - Proceedings of the …, 2009 - National Acad Sciences
The human MHC represents the strongest susceptibility locus for autoimmune diseases.
However, the identification of the true predisposing gene (s) has been handicapped by the …
However, the identification of the true predisposing gene (s) has been handicapped by the …
Evolving views of the major histocompatibility complex
JR Gruen, SM Weissman - Blood, The Journal of the American …, 1997 - ashpublications.org
HE MAJOR HISTOCOMPATIBILITY complex (MHC) is an extended cluster of genes that are
remarkable for the number and importance of the immunological functions The MHC is of …
remarkable for the number and importance of the immunological functions The MHC is of …
Molecular mechanisms for contribution of MHC molecules to autoimmune diseases
Highlights•The MHC is the most important genetic risk factor in common autoimmune
diseases.•For one disease there can be independent contributions by several distinct MHC …
diseases.•For one disease there can be independent contributions by several distinct MHC …