Obesity, leptin and breast cancer: epidemiological evidence and proposed mechanisms

S Andò, L Gelsomino, S Panza, C Giordano… - Cancers, 2019 - mdpi.com
The prevalence of obesity has been steadily increasing over the past few decades in several
developed and developing countries, with resultant hazardous health implications …

Obesity and breast cancer: role of leptin

F Sánchez-Jiménez, A Pérez-Pérez… - Frontiers in …, 2019 - frontiersin.org
Obesity-related breast cancer is an important threat that affects especially post-menopausal
women. The link between obesity and breast cancer seems to be relying on the …

Obesity and breast cancer: status of leptin and adiponectin in pathological processes

ME Grossmann, A Ray, KJ Nkhata… - Cancer and Metastasis …, 2010 - Springer
It is well recognized that obesity increases the risk of various cancers, including breast
malignancies in postmenopausal women. Furthermore, obesity may adversely affect tumor …

Circulating levels of leptin, adiposity and breast cancer risk

MH Wu, YC Chou, WY Chou, GC Hsu, CH Chu… - British journal of …, 2009 - nature.com
The present case–control study was to investigate the relationships of plasma leptin level
and anthropometric measures of adiposity with the risk of breast cancer. Questionnaire …

Linkage between obesity leptin and breast cancer

MF Atoum, F Alzoughool… - Breast Cancer: Basic …, 2020 - journals.sagepub.com
Many cancers might be influenced by obesity, including breast cancer, the leading cause of
cancer death among women. Obesity is a complex state associated with multiple …

Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin

DP Rose, EM Gilhooly… - … journal of oncology, 2002 - spandidos-publications.com
Leptin is a hormone with multiple biological actions which is produced predominantly by
adipose tissue; in humans, plasma levels correlate with total body fat, and particularly high …

The integrative role of leptin, oestrogen and the insulin family in obesity‐associated breast cancer: potential effects of exercise

S Schmidt, JM Monk, LE Robinson… - Obesity …, 2015 - Wiley Online Library
Obesity is an established risk factor for postmenopausal breast cancer. The mechanisms
through which obesity influences the development and progression of breast cancer are not …

The weight of obesity in breast cancer progression and metastasis: Clinical and molecular perspectives

I Barone, C Giordano, D Bonofiglio, S Ando… - Seminars in cancer …, 2020 - Elsevier
The escalating epidemic of overweight and obesity is currently recognized as one of the
most significant health and economic concern worldwide. At the present time, over 1.9 billion …

Obesity hormone leptin: a new target in breast cancer?

E Surmacz - Breast Cancer Research, 2007 - Springer
Leptin is a multifunctional hormone produced mainly by the adipose tissue and involved in
the regulation of food intake and energy balance. In addition, leptin can stimulate mitogenic …

Leptin, obesity and breast cancer: progress to understanding the molecular connections

I Barone, C Giordano, D Bonofiglio, S Andò… - Current Opinion in …, 2016 - Elsevier
Highlights•Obesity is a pandemic condition associated with both risk and prognosis of breast
cancer.•The adipokine leptin is a plausible molecular link between obesity and breast …