Advances in platelet function testing—light transmission aggregometry and beyond

J Le Blanc, F Mullier, C Vayne… - Journal of clinical …, 2020 - mdpi.com
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there
are many methods used to test platelet function for research purposes, standardization is …

[HTML][HTML] Platelet preparation for function testing in the laboratory and clinic: Historical and practical aspects

B Hechler, A Dupuis, PH Mangin, C Gachet - Research and practice in …, 2019 - Elsevier
Laboratory tests of platelet function are instrumental in studying platelet physiology and
inherited or acquired platelet abnormalities. Light transmission aggregometry, developed in …

Laboratory testing for platelet function disorders

SJ Israels - International Journal of Laboratory Hematology, 2015 - Wiley Online Library
Platelet function testing is both complex and labor intensive. A stepwise approach to the
evaluation of patients with suspected platelet disorders will optimize the use of laboratory …

Light transmission aggregometry

JP Frontroth - Haemostasis: methods and protocols, 2013 - Springer
Laboratory testing of platelet function is essential for the diagnosis of several congenital and
acquired platelet disorders. Moreover, it is increasingly being utilized to monitor the efficacy …

[PDF][PDF] Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of …

M Cattaneo, CPM Hayward, KA Moffat… - Journal of Thrombosis …, 2009 - academia.edu
Background: Light transmission aggregometry (LTA) is the most common method used in
clinical and research laboratories to assess platelet function. However, the method has …

[HTML][HTML] Validation of flow cytometric analysis of platelet function in patients with a suspected platelet function defect

I Van Asten, REG Schutgens, M Baaij… - Journal of Thrombosis …, 2018 - Elsevier
Essentials• The diagnosis of mild platelet function disorders (PFDs) is challenging.•
Validation of flow cytometric testing in patients with suspected PFDs is required.• Flow …

The level of laboratory testing required for diagnosis or exclusion of a platelet function disorder using platelet aggregation and secretion assays

D Mezzano, T Quiroga, J Pereira - Seminars in thrombosis and …, 2009 - thieme-connect.com
The major advances from research on platelet molecular and cell biology, physiology, and
pathophysiology over the past decades have not been adequately translated to clinical …

Platelet function analysis

P Harrison - Blood reviews, 2005 - Elsevier
Since the last guidelines for BCSH platelet function testing were written in the late 1980s,
many new tests have become available. Previously most platelet function tests were …

Platelet function testing: update and future directions

JB Larsen, AM Hvas, JA Hojbjerg - Seminars in Thrombosis …, 2023 - thieme-connect.com
Platelets play a key role in maintaining normal hemostasis and are also recognized as
partners in the development of arterial thrombosis. Today, platelet function testing is used for …

Centrifugation speed affects light transmission aggregometry

M Merolla, MA Nardi, JS Berger - International journal of …, 2012 - Wiley Online Library
Background: Light transmission aggregometry (LTA) is considered the gold standard for
investigating platelet activity ex vivo. However, LTA protocols are not standardized, and …