Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …

Catalytic selective hydroxylation of unactivated aliphatic (sp3) C− H bonds without a
directing group represents a formidable task for synthetic chemists. Through directed …

It is a great challenge to optionally access diverse hydroxylation products from a given
substrate bearing multiple reaction sites of sp3 and sp2 C− H bonds. Herein, we report the …

The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds
continues to progress at a rapid pace due to the significant economic and environmental …

Aliphatic C− H oxidation is the most straightforward approach to functionalize hydrocarbon
skeletons. The main challenge of this reaction is the control of site selectivity, given the …

Regioselective hydroxylation of aromatic rings is a “dream reaction” in organic chemistry
and is of high interest for the production of precursors for pharmaceuticals and flavors. In …

Enzymes have emerged in recent decades as ideal catalysts for synthetic transformations
under mild reaction conditions. Their capacity to accelerate a myriad of biotransformations …

The direct hydroxylation of alkanes under mild conditions is a key issue in catalytic chemistry
that addresses an increasing number of industrial and economic requirements. Cytochrome …

Cytochrome P450 enzymes (P450s) are exceptional oxygenating catalysts [1] with
enormous potential in drug discovery, chemical synthesis, bioremediation, and …

Cytochrome P450 enzymes catalyze a broad set of C–H activation reactions, the most
prominent being hydroxylation. This review provides an overview of the regioselectivity (CH …