Alternative oxidase impacts ganoderic acid biosynthesis by regulating intracellular ROS levels in Ganoderma lucidum

DK Shi, J Zhu, ZH Sun, G Zhang, R Liu… - …, 2017 - microbiologyresearch.org
The alternative oxidase (AOX), which forms a branch of the mitochondrial respiratory
electron transport pathway, functions to sustain electron flux and alleviate reactive oxygen …

[HTML][HTML] Effects of glutamate oxaloacetate transaminase on reactive oxygen species in Ganoderma lucidum

H Liu, J Qiao, J Shangguan, J Zhu - Applied Microbiology and …, 2023 - Springer
Nitrogen metabolism can regulate mycelial growth and secondary metabolism in
Ganoderma lucidum. As an important enzyme in intracellular amino acid metabolism …

Cross talk between GlAQP and NOX modulates the effects of ROS balance on ganoderic acid biosynthesis of Ganoderma lucidum under water stress

Q Zhu, A Ren, J Ding, J He, M Zhao, A Jiang… - Microbiology …, 2022 - Am Soc Microbiol
Water stress affects both the growth and development of filamentous fungi; however, the
mechanisms underlying their response to water stress remain unclear. In this study, water …

[HTML][HTML] SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum

R Liu, P Cao, A Ren, S Wang, T Yang, T Zhu, L Shi… - Redox Biology, 2018 - Elsevier
Ganoderma lucidum has high commercial value because it produces many active
compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to …

Functional analysis of the role of glutathione peroxidase (GPx) in the ROS signaling pathway, hyphal branching and the regulation of ganoderic acid biosynthesis in …

C Li, L Shi, D Chen, A Ren, T Gao, M Zhao - Fungal Genetics and Biology, 2015 - Elsevier
Ganoderma lucidum, a hallmark of traditional Chinese medicine, has been widely used as a
pharmacologically active compound. Although numerous research studies have focused on …

[HTML][HTML] Nitrate reductase-dependent nitric oxide plays a key role on MeJA-induced ganoderic acid biosynthesis in Ganoderma lucidum

L Shi, S Yue, T Gao, J Zhu, A Ren, H Yu… - Applied Microbiology …, 2020 - Springer
Ganoderma lucidum, which contains numerous biologically active compounds, is known
worldwide as a medicinal basidiomycete. Because of its application for the prevention and …

Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial …

Q Wang, M Xu, L Zhao, F Wang, Y Li… - Microbial …, 2021 - Wiley Online Library
Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited
many significant pharmacological activities. In this study, the biosynthetic mechanism of GAs …

Shedding light on the mechanisms underlying the environmental regulation of secondary metabolite ganoderic acid in Ganoderma lucidum using physiological and …

A Ren, L Shi, J Zhu, H Yu, A Jiang, H Zheng… - Fungal genetics and …, 2019 - Elsevier
The secondary metabolites of fungi are often produced at very low concentrations, and until
recently the regulatory mechanisms of secondary metabolite biosynthesis have been …

[HTML][HTML] Biosynthesis of a novel ganoderic acid by expressing CYP genes from Ganoderma lucidum in Saccharomyces cerevisiae

WF Wang, H Xiao, JJ Zhong - Applied Microbiology and Biotechnology, 2022 - Springer
Ganoderic acids (GAs), a group of highly oxygenated lanostane-type triterpenoids from the
traditional Chinese medicinal mushroom Ganoderma lucidum, possessed significant …

Functions of reactive oxygen species in apoptosis and ganoderic acid biosynthesis in Ganoderma lucidum

J Zhu, F Wu, S Yue, C Chen, S Song… - FEMS Microbiology …, 2019 - academic.oup.com
Ganoderma lucidum is a medicinal fungus that is widely used in traditional medicine. Fungal
PacC is recognized as an important transcription factor that functions during adaptation to …