Surfactant proteins A and D (SP-A and-D) play a role in many acute bacterial, viral, and
fungal infections and in acute allergic responses. In vitro, human SPs bind Mycobacterium …

Abstract Surfactant protein-D (SP-D) is a collectin produced in the distal lung airspaces that
is believed to play an important role in innate pulmonary immunity. Naive immunologic …

Tuberculosis leads to immune activation and increased human immunodeficiency virus type
1 (HIV-1) replication in the lung. However, in vitro models of mycobacterial infection of …

The innate immune system in the lung is essential for controlling infections due to inhaled
pathogens. Mycobacterium tuberculosis (M. tb) encounters components of the innate …

Attachment of Mycobacterium tuberculosis organisms to alveolar macrophages (AMs) is an
essential early event in primary pulmonary tuberculosis. Surfactant protein A (SP-A) is a …

During initial infection with Mycobacterium tuberculosis, bacteria that reach the distal
airspaces of the lung are phagocytosed by alveolar macrophages in the presence of …

We have shown previously that surfactant protein D (SP-D) binds and agglutinates
Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against …

The incidence of tuberculosis is increasing on a global scale, in part due to its strong
association with human immunodeficiency virus (HIV) infection. Attachment of …

Abstract Surfactant protein A (SP-A) suppresses lymphocyte proliferation and IL-2 secretion,
in part, by binding to its receptor, SP-R210. However, the mechanisms underlying this effect …

Mycobacterium tuberculosis comes in contact with pulmonary surfactant, alveolar
macrophages and type II epithelial cells. Alveolar type II epithelial cells secrete pulmonary …