BACKGROUND The presence of Spigelman stage (SS) IV duodenal polyposis is considered
the most significant risk factor for duodenal cancer in patients with MUTYH-associated …

Background & Aims MUTYH-associated polyposis (MAP) is similar to familial adenomatous
polyposis (FAP), in that it increases the risk for duodenal adenomas and cancer. Almost all …

BACKGROUND & AIMS: MUTYH-associated polyposis (MAP) is characterized by a lifetime
risk of colorectal cancer of up to 100%. However, no systematic evaluation of extracolonic …

Background and aim MUTYH-associated polyposis (MAP) is an autosomal recessive
inherited disorder characterised by the development of polyposis in the upper and lower …

1Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University, School of
Medicine, Cardiff, UK; 2Department of Gastroenterology, Prince Charles Hospital, Merthyr …

Aim The aim was to determine the presentation, management and outcomes of MUTYH‐
associated polyposis (MAP). Method A prospectively maintained database was used to …

Background MUTYH-associated polyposis is a recessively inherited disorder characterized
by a lifetime risk of colorectal cancer that is up to 100%. Because specific histological and …

PURPOSE: The risk of cancer or severe polyposis of the rectal stump after total colectomy for
MutYH-associated polyposis is scarcely defined. To evaluate this risk, we describe the …

Purpose Biallelic germ-line mutations in MUTYH have recently been found to predispose for
MUTYH-associated polyposis (MAP). Affected patients present with a wide range of clinical …

MUTYH-associated polyposis was first described in 2002. It is inherited recessively, and
patients usually develop between tens and hundreds of adenomas throughout life. The risk …