[HTML][HTML] Molecular mechanisms and biological functions of siRNA
H Dana, GM Chalbatani… - … journal of biomedical …, 2017 - ncbi.nlm.nih.gov
One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …
Current progress of siRNA/shRNA therapeutics in clinical trials
Through a mechanism known as RNA interference (RNAi), small interfering RNA (siRNA)
molecules can target complementary mRNA strands for degradation, thus specifically …
molecules can target complementary mRNA strands for degradation, thus specifically …
Strategies for In Vivo Delivery of siRNAs: Recent Progress
Y Higuchi, S Kawakami, M Hashida - BioDrugs, 2010 - Springer
RNA interference (RNAi) is a post-transcriptional gene-silencing mechanism that involves
the degradation of messenger RNA in a highly sequence-specific manner. Double-stranded …
the degradation of messenger RNA in a highly sequence-specific manner. Double-stranded …
[HTML][HTML] Therapeutic siRNA: state of the art
ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …
against external invasion. It theoretically can silence any disease-related genes in a …
[HTML][HTML] Engineering siRNA therapeutics: challenges and strategies
SS Ali Zaidi, F Fatima, SA Ali Zaidi, D Zhou… - Journal of …, 2023 - Springer
Small interfering RNA (siRNA) is a potential method of gene silencing to target specific
genes. Although the US Food and Drug Administration (FDA) has approved multiple siRNA …
genes. Although the US Food and Drug Administration (FDA) has approved multiple siRNA …
siRNA: Mechanism of action, challenges, and therapeutic approaches
W Alshaer, H Zureigat, A Al Karaki, A Al-Kadash… - European journal of …, 2021 - Elsevier
Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …
become an essential approach in treating a variety of infectious, hemato-oncological …
Strategies, design, and chemistry in siRNA delivery systems
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
Ligand-targeted delivery of therapeutic siRNA
Y Ikeda, K Taira - Pharmaceutical research, 2006 - Springer
RNA interference (RNAi) is a post-transcriptional gene-silencing phenomenon that is
triggered by double-stranded RNA (dsRNA). Since many diseases are associated with the …
triggered by double-stranded RNA (dsRNA). Since many diseases are associated with the …
Gene silencing mediated by small interfering RNAs in mammalian cells
M Scherr, MA Morgan, M Eder - Current medicinal chemistry, 2003 - ingentaconnect.com
RNA interference (RNAi) as a protecting mechanism against invasion by foreign genes was
first described in C. elegans and has subsequently been demonstrated in diverse …
first described in C. elegans and has subsequently been demonstrated in diverse …
Cellular delivery in vivo of siRNA-based therapeutics
A Aigner - Current pharmaceutical design, 2008 - ingentaconnect.com
RNAi interference (RNAi) is an almost standard method for the knockdown of any target
gene of interest in vitro, exploring a naturally occurring catalytic mechanism. Beyond …
gene of interest in vitro, exploring a naturally occurring catalytic mechanism. Beyond …