Antibacterial resistance to β-lactams in microorganisms has been attributed majorly to
alterations in penicillin-binding proteins (PBPs) coupled with β-lactams' inactivation by β …

Data implicating the mutation in penicillin-binding protein (PBP) 3 and occasionally PBP5 in
the resistance of Escherichia coli to beta− lactams is intriguing. Thus, the identification of an …

Infections caused by multidrug-resistant Streptococcus pneumoniae remain the leading
cause of pneumonia-related deaths in children< 5 years globally, and mutations in penicillin …

The acquisition of penicillin-binding protein (PBP) 2a in resistant strains of Staphylococcus
aureus allows for the continuous production of cell walls even after the inactivation of …

Abstract Methicillin-Resistant Staphylococcus aureus (MRSA), a pathogenic bacterium that
causes life-threatening outbreaks such as community-onset and nosocomial infections as …

Methicillin‐resistant Staphylococcus aureus (MRSA) has evolved resistance even against
the last resort β‐lactam antibiotics. This is because of the acquisition of an additional …

Gonococcal infections present a notable public health issue, and the major approach for
treatment involves using β‐lactam antibiotics that specifically target penicillin‐binding …

Abstract β‐Lactam antibiotics are critical antibacterial agents and have rapidly become
active ingredients in modern medicine. On the other hand, in the face of increasing rate of …

The conventional course of drug discovery is a lengthy, expensive and complex process and
often experiences a high failure rate. This in-silico based study screened novel drug …

Bacterial resistance to β-lactam antibiotics poses a serious threat to human health. Penicillin
binding proteins (PBPs) and β-lactamases are involved in both antibacterial activity and …