Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles

SA Dick, A Wong, H Hamidzada, S Nejat… - Science …, 2022 - science.org
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is
appreciated that different tissues instruct specialized macrophage functions. However …

Macrophages: development and tissue specialization

C Varol, A Mildner, S Jung - Annual review of immunology, 2015 - annualreviews.org
Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

Tissue-specific macrophages: how they develop and choreograph tissue biology

E Mass, F Nimmerjahn, K Kierdorf… - Nature Reviews …, 2023 - nature.com
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Origin, development, and homeostasis of tissue‐resident macrophages

M Haldar, KM Murphy - Immunological reviews, 2014 - Wiley Online Library
Macrophages are versatile cells of the hematopoietic system that display remarkable
functional diversity encompassing innate immune responses, tissue development, and …

Developmental origin of lung macrophage diversity

SYS Tan, MA Krasnow - Development, 2016 - journals.biologists.com
Macrophages are specialized phagocytic cells, present in all tissues, which engulf and
digest pathogens, infected and dying cells, and debris, and can recruit and regulate other …

Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues

J Qie, Y Liu, Y Wang, F Zhang, Z Qin, S Tian… - Nature …, 2022 - nature.com
Macrophages are involved in tissue homeostasis and are critical for innate immune
responses, yet distinct macrophage populations in different tissues exhibit diverse gene …

Tissue biology perspective on macrophages

Y Okabe, R Medzhitov - Nature immunology, 2016 - nature.com
Macrophages are essential components of mammalian tissues. Although historically known
mainly for their function in host defense and the clearance of apoptotic cells, macrophages …

[HTML][HTML] Determinants of resident tissue macrophage identity and function

C Blériot, S Chakarov, F Ginhoux - Immunity, 2020 - cell.com
Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

A common framework of monocyte-derived macrophage activation

DE Sanin, Y Ge, E Marinkovic, AM Kabat… - Science …, 2022 - science.org
Macrophages populate every organ during homeostasis and disease, displaying features of
tissue imprinting and heterogeneous activation. The disconnected picture of macrophage …

Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities

CC Bain, CA Hawley, H Garner, CL Scott… - Nature …, 2016 - nature.com
Peritoneal macrophages are one of the most studied macrophage populations in the body,
yet the composition, developmental origin and mechanisms governing the maintenance of …