In silico molecular docking analysis of karanjin against alzheimer's and parkinson's diseases as a potential natural lead molecule for new drug design, development …

C Gnanaraj, M Sekar, S Fuloria, SS Swain, SH Gan… - Molecules, 2022 - mdpi.com
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
that have emerged as among the serious health problems of the 21st century. The …

Deciphering the interactions of bioactive compounds in selected traditional medicinal plants against Alzheimer's diseases via pharmacophore modeling, auto-QSAR …

OA Ojo, AB Ojo, C Okolie, MAC Nwakama… - Molecules, 2021 - mdpi.com
Neurodegenerative diseases, for example Alzheimer's, are perceived as driven by
hereditary, cellular, and multifaceted biochemical actions. Numerous plant products, for …

Combined computational approaches for developing new anti-Alzheimer drug candidates: 3D-QSAR, molecular docking and molecular dynamics studies of …

H Nour, O Daoui, O Abchir, S ElKhattabi, S Belaidi… - Heliyon, 2022 - cell.com
Butyrylcholinesterase is an acetylcholine-degrading enzyme involved in the memorization
process, which is becoming an interesting target for the symptomatic treatment of …

Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: A computational investigation

F Azam, AM Amer, AR Abulifa… - … design, development and …, 2014 - Taylor & Francis
Ginger (Zingiber officinale), despite being a common dietary adjunct that contributes to the
taste and flavor of foods, is well known to contain a number of potentially bioactive …

Virtual screening, pharmacokinetics, molecular dynamics and binding free energy analysis for small natural molecules against cyclin-dependent kinase 5 for …

R Shukla, TR Singh - Journal of Biomolecular Structure and …, 2020 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and characterized by
brain cell death, memory loss and is the most common form of dementia. Although AD has …

Docking simulation and ADMET prediction based investigation on the phytochemical constituents of Noni (Morinda citrifolia) fruit as a potential anticancer drug

K Chandran, DI Shane, A Zochedh, AB Sultan… - In Silico …, 2022 - Springer
Morinda citrifolia is a traditional plant used in Asian and African countries for its wide
nutraceutical and therapeutic effects for the treatment of various ailments. The fruit of M …

Investigation of Cannabis sativa Phytochemicals as Anti-Alzheimer's Agents: An In Silico Study

N Patil, V Chandel, A Rana, M Jain, P Kaushik - Plants, 2023 - mdpi.com
Cannabis sativa is a medicinal plant that has been known for years and is used as an
Ayurvedic medicine. This plant has great potential in treating various types of brain …

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

MS Rahman, MNH Zilani, MA Islam, MM Hasan… - Processes, 2021 - mdpi.com
Medicinal plants possess a surplus of novel and biologically active secondary metabolites
that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) …

Identifying natural compounds as multi-target-directed ligands against Alzheimer's disease: an in silico approach

P Ambure, J Bhat, T Puzyn, K Roy - Journal of Biomolecular …, 2019 - Taylor & Francis
Alzheimer's disease (AD) is a multi-factorial disease, which can be simply outlined as an
irreversible and progressive neurodegenerative disorder with an unclear root cause. It is a …

Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease

P Meena, V Nemaysh, M Khatri, A Manral… - Bioorganic & medicinal …, 2015 - Elsevier
Abstract Development of Multi-Target Directed Ligands (MTDLs) has emerged as a
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …