Developing a novel immune-related seven-gene signature and immune infiltration pattern in patients with COVID-19 and cardiovascular disease

Y Fu, J Zhang, L Xu, H Zhang, S Ma, Y Gao… - Journal of …, 2022 - mdpi.com
Background: patients with pre-existence of cardiovascular disease (CVD) are vulnerable to
coronavirus disease 2019 (COVID-19), and COVID-19 will cause long-term burden of CVD …

Bioinformatics and systems biology approaches to identify molecular targeting mechanism influenced by COVID-19 on heart failure

K Yang, J Liu, Y Gong, Y Li, Q Liu - Frontiers in immunology, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has emerged as a contemporary hazard to people. It has been …

Genetic and immunological insights into COVID-19 with acute myocardial infarction: integrated analysis of mendelian randomization, transcriptomics, and clinical …

Z Zheng, Y Zhou, Y Song, P Ying, X Tan - Frontiers in Immunology, 2023 - frontiersin.org
Background Globally, most deaths result from cardiovascular diseases, particularly ischemic
heart disease. COVID-19 affects the heart, worsening existing heart conditions and causing …

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

H Bräuninger, B Stoffers, ADE Fitzek… - Cardiovascular …, 2022 - academic.oup.com
Aims Cardiac involvement in COVID-19 is associated with adverse outcome. However, it is
unclear whether cell-specific consequences are associated with cardiac SARS-CoV-2 …

High expression of IL6 and decrease in immune cells in COVID-19 patients combined with myocardial injury

T Chen, H Chen, P Chen, L Zhu, W Mao… - Frontiers in …, 2023 - frontiersin.org
Purpose Myocardial injury, as a serious complication of coronavirus disease-2019 (COVID-
19), increases the occurrence of adverse outcomes. Identification of key regulatory …

Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era

Q Cao, X Du, X Jiang, Y Tian, C Gao, Z Liu… - Acta Pharmacologica …, 2023 - nature.com
SARS-CoV-2 infection causes injuries of not only the lungs but also the heart and
endothelial cells in vasculature of multiple organs, and induces systemic inflammation and …

[HTML][HTML] Identification of key molecules in COVID-19 patients significantly correlated with clinical outcomes by analyzing transcriptomic data

Z Dong, Q Yan, W Cao, Z Liu, X Wang - Frontiers in immunology, 2022 - frontiersin.org
Background Although several key molecules have been identified to modulate SARS-CoV-2
invasion of human host cells, the molecules correlated with outcomes in COVID-19 caused …

Comprehensive bioinformatics analysis and systems biology approaches to identify the interplay between COVID-19 and pericarditis

D Li, R Chen, C Huang, G Zhang, Z Li, X Xu… - Frontiers in …, 2024 - frontiersin.org
Background Increasing evidence indicating that coronavirus disease 2019 (COVID-19)
increased the incidence and related risks of pericarditis and whether COVID-19 vaccine is …

COVID-19 severity potentially modulated by cardiovascular-disease-associated immune dysregulation

AC Lee, G Castaneda, WT Li, C Chen, N Shende… - Viruses, 2021 - mdpi.com
Patients with underlying cardiovascular conditions are particularly vulnerable to severe
COVID-19. In this project, we aimed to characterize similarities in dysregulated immune …

Identification of Comorbidities, Genomic Associations, and Molecular Mechanisms for COVID‐19 Using Bioinformatics Approaches

SBS Omit, S Akhter, HK Rana… - BioMed Research …, 2023 - Wiley Online Library
Several studies have been done to identify comorbidities of COVID‐19. In this work, we
developed an analytical bioinformatics framework to reveal COVID‐19 comorbidities, their …