Characterization of Beta3-Adrenoceptors in Human Internal Mammary Artery and Putative Involvement in Coronary Artery Bypass Management

B Rozec, S Serpillon, G Toumaniantz, C Sèze… - Journal of the American …, 2005 - jacc.org
Objectives: The aim of the present study was to analyze whether beta3-adrenoceptors (β3-
ARs) were effectively present and functional in the human internal mammary artery (IMA) …

Predominant α1Adrenoceptor-Mediated Contraction in the Human Internal Mammary Artery

GW He, J Shaw, CF Hughes, CQ Yang… - Journal of …, 1993 - journals.lww.com
[alpha]-Adrenoceptor agonists and antagonists are widely used perioperatively for internal
mammary artery (IMA)-coronary artery bypass operations. To determine subtypes of a …

The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries

BC Jensen, PM Swigart, ME Laden, T DeMarco… - Journal of the American …, 2009 - jacc.org
Objectives: The goal was to identify alpha-1-adrenergic receptor (AR) subtypes in human
coronary arteries. Background: The α1-ARs regulate human coronary blood flow. The α1 …

β3-Adrenoceptors in the cardiovascular system: putative roles in human pathologies

B Rozec, C Gauthier - Pharmacology & therapeutics, 2006 - Elsevier
The sympathetic nervous system is central for the neurohumoral regulation of the
cardiovascular system and is largely involved in many cardiovascular diseases affecting …

Endothelial β3-Adrenoceptors Mediate Vasorelaxation of Human Coronary Microarteries Through Nitric Oxide and Endothelium-Dependent Hyperpolarization

C Dessy, S Moniotte, P Ghisdal, X Havaux… - Circulation, 2004 - Am Heart Assoc
Background—Coronary vessel tone is modulated in part by β-adrenergic relaxation.
However, the implication of specific β-adrenoceptor subtypes and their downstream …

Coexistence of at least three distinct beta-adrenoceptors in human internal mammary artery

M Shafiei, G Omrani, M Mahmoudian - Acta Physiologica Hungarica, 2000 - akjournals.com
The internal mammary artery (IMA) is currently the preferred conduit for myocardial
revascularization. However, perioperative vasospasm and a hypoperfusion state during …

Beta3-adrenergic receptors in cardiac and vascular tissues: emerging concepts and therapeutic perspectives

C Dessy, JL Balligand - Advances in pharmacology, 2010 - Elsevier
Catecholamines released by the orthosympathetic system play a major role in the short-and
long-term regulation of cardiovascular function. Beta1-and beta2-adrenoreceptors (ARs) …

Beta 3‐adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway

Y Rautureau, G Toumaniantz… - British journal of …, 2002 - Wiley Online Library
We have previously demonstrated that β3‐adrenoceptor (β3‐AR) stimulation induces
endothelium‐dependent vasorelaxation in rat aorta through the activation of an endothelial …

[HTML][HTML] The beta3 adrenergic receptor in healthy and pathological cardiovascular tissues

LYM Michel, C Farah, JL Balligand - Cells, 2020 - mdpi.com
The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …

[HTML][HTML] Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells

BC Jensen, PM Swigart, MD Montgomery… - Naunyn-Schmiedeberg's …, 2010 - Springer
Abstract Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by
binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing …