To explore physiological roles of BCL-W, a prosurvival member of the BCL-2 protein family,
we generated transgenic (TG) mice overexpressing Bcl-w driven by a chicken β-actin …

Expression of bcl-w, a close relative of bcl-2 is essential for male fertility in mice. Although
the initial wave of spermatogenesis in bcl-w−/− mice proceeds normally until 3–4 weeks of …

Male mice deficient in BCLW, a death-protecting member of the BCL2 family, are sterile due
to an arrest in spermatogenesis that is associated with a gradual loss of germ cells and …

To explore the functional role of Bcl‐2 in germ cell development, transgenic mice carrying 6
kilobases of the inhibin‐α promoter were generated to express human bcl‐2 gene product in …

Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

Bcl-w, a prosurvival member of the Bcl-2 family, is essential for spermatogenesis. However,
the mechanisms by which Bcl-w participates in the regulation of apoptosis in the testis are …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

Restricted germ cell loss through apoptosis is initiated in the fetal gonad around embryonic
day 13.5 (E13. 5) as part of normal germ cell development. The mechanism of this germ cell …

The growth, differentiation, and death/survival of spermatogonia are precisely regulated for
the proper production of spermatozoa. We have previously shown that Bcl‐2 ectopically …

To identify genes required for mammalian spermatogenesis, we screened lines of mutant
mice created using a retroviral genetrap system1 for male infertility. Homozygous ROSA41 …