Stress, inflammation, depression, and dementia associated with phosphate toxicity

RB Brown - Molecular Biology Reports, 2020 - Springer
Depression and dementia are predicted to increase within aging global populations.
Pathophysiological effects of phosphate toxicity, dysregulated amounts of accumulated …

Dietary phosphate toxicity: an emerging global health concern

S Erem, MS Razzaque - Histochemistry and cell biology, 2018 - Springer
Phosphate is a common ingredient in many healthy foods but, it is also present in foods
containing additives and preservatives. When found in foods, phosphate is absorbed in the …

[HTML][HTML] Parkinson's disease etiology: insights and associations with phosphate toxicity

RB Brown - International Journal of Molecular Sciences, 2022 - mdpi.com
The present paper investigated the association of Parkinson's disease etiology with
phosphate toxicity, a pathophysiological condition in which dysregulated phosphate …

Phosphate toxicity: a stealth biochemical stress factor?

RB Brown, MS Razzaque - Medical molecular morphology, 2016 - Springer
Phosphate is an essential mineral component of the human body, and therefore, its
dysregulation can affect the functionality of almost all the organ systems. Both organic and …

[HTML][HTML] Phosphate dysregulation and metabolic syndrome

N Mironov, M Haque, A Atfi, MS Razzaque - Nutrients, 2022 - mdpi.com
Phosphorus is one of the most abundant minerals in the human body. It is essential for
almost all biochemical activities through ATP formation, intracellular signal transduction, cell …

Dysregulated phosphate metabolism in autism spectrum disorder: associations and insights for future research

RB Brown - Expert Reviews in Molecular Medicine, 2023 - cambridge.org
Studies of autism spectrum disorder (ASD) related to exposure to toxic levels of dietary
phosphate are lacking. Phosphate toxicity from dysregulated phosphate metabolism can …

The emerging role of phosphorus in human health

RP Bird, NAM Eskin - Advances in food and Nutrition Research, 2021 - Elsevier
Phosphorus, an essential nutrient, performs vital functions in skeletal and non-skeletal
tissues and is pivotal for energy production. The last two decades of research on the …

[HTML][HTML] Excessive inorganic phosphate burden perturbed intracellular signaling: quantitative proteomics and phosphoproteomics analyses

R Hetz, E Beeler, A Janoczkin, S Kiers, L Li… - Frontiers in …, 2022 - frontiersin.org
Inorganic phosphate (Pi) is an essential nutrient for the human body which exerts adverse
health effects in excess and deficit. High Pi-mediated cytotoxicity has been shown to induce …

Biological effects of inorganic phosphate: potential signal of toxicity

SH Hong, SJ Park, S Lee, S Kim… - The Journal of …, 2015 - jstage.jst.go.jp
Inorganic phosphate (Pi) plays crucial roles in several biological processes and signaling
pathways. Pi uptake is regulated by sodium-dependent phosphate (Na/Pi) transporters …

High phosphate actively induces cytotoxicity by rewiring pro‐survival and pro‐apoptotic signaling networks in HEK293 and HeLa cells

P He, O Mann‐Collura, J Fling, N Edara… - The FASEB …, 2021 - Wiley Online Library
Inorganic phosphate (Pi) is an essential nutrient for human health. Due to the changes in our
dietary pattern, dietary Pi overload engenders systemic phosphotoxicity, including excessive …