SeXX matters in multiple sclerosis

F Gilli, KD DiSano, AR Pachner - Frontiers in neurology, 2020 - frontiersin.org
Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative
disease of the central nervous system (CNS). An interesting feature that this debilitating …

The importance of studying sex differences in disease: The example of multiple sclerosis

LC Golden, R Voskuhl - Journal of neuroscience research, 2017 - Wiley Online Library
To date, scientific research has often focused on one sex, with assumptions that study of the
other sex would yield similar results. However, many diseases affect males and females …

The effect of sex on multiple sclerosis risk and disease progression

RR Voskuhl - Multiple Sclerosis Journal, 2020 - journals.sagepub.com
Sex differences in the incidence or severity of disease characterize many autoimmune and
neurodegenerative diseases. Multiple sclerosis is a complex disease with both autoimmune …

Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis

C Ramien, A Taenzer, A Lupu, N Heckmann… - Neuroscience & …, 2016 - Elsevier
Clinical observations in human autoimmune diseases such as multiple sclerosis (MS)
suggest a pivotal role of sex-related factors in the etiopathogenesis. These include a female …

Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms

JM Greer, PA McCombe - Journal of neuroimmunology, 2011 - Elsevier
Multiple sclerosis (MS) is more prevalent in females than males, and this female
predominance is increasing as time goes by. Additionally, gender appears to play critical …

The role of gender and sex hormones in determining the onset and outcome of multiple sclerosis

R Bove, T Chitnis - Multiple Sclerosis Journal, 2014 - journals.sagepub.com
Intriguing sex differences both in multiple sclerosis (MS) susceptibility and its disease course
may offer important insights into MS disease pathophysiology, prevention and treatment. In …

A case of double standard: Sex differences in multiple sclerosis risk factors

B Angeloni, R Bigi, G Bellucci, R Mechelli… - International Journal of …, 2021 - mdpi.com
Multiple sclerosis is a complex, multifactorial, dysimmune disease prevalent in women. Its
etiopathogenesis is extremely intricate, since each risk factor behaves as a variable that is …

Age‐dependent variation of female preponderance across different phenotypes of multiple sclerosis: A retrospective cross‐sectional study

A Miclea, A Salmen, G Zoehner, L Diem… - CNS neuroscience & …, 2019 - Wiley Online Library
Introduction Multiple sclerosis (MS) is an autoimmune disease of the CNS, which
predominantly affects women. Studies investigating the sex distribution in MS are sparse …

Sexual disparities in the incidence and course of MS

R Bove, T Chitnis - Clinical Immunology, 2013 - Elsevier
Multiple sclerosis (MS) affects three times more women than men and this ratio appears to
be increasing. However male patients experience increased disease progression, brain …

Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression

RR Voskuhl, AH Sawalha, Y Itoh - Multiple Sclerosis Journal, 2018 - journals.sagepub.com
Background: Why are women more susceptible to multiple sclerosis, but men have worse
disability progression? Sex differences in disease may be due to sex hormones, sex …