Rationale: Cyclosporin A (CsA) is known to preserve cardiac contractile function during
endotoxemia, but the mechanism is unclear. Increased nitric oxide (NO) production and …

Objective: Growing evidence suggests that mitochondria function is impaired in sepsis.
Here, we tested the hypothesis that lipopolysaccharide would induce mitochondrial Ca 2+ …

The mechanism responsible for cardiac depression in septic shock remains unknown. The
present study examined whether nitric oxide (NO) overproduced by inducible NO synthase …

Sepsis elicits severe alterations in cardiac function, impairing cardiac mitochondrial and
pressure-generating capacity. Currently, there are no therapies to prevent sepsis-induced …

Objectives: The purpose of this study was to test whether mitochondrial dysfunction is
causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation …

Myocardial depression can be demonstrated following administration of endotoxin.
Proposed mechanisms of endotoxin-induced myocardial dysfunction include the release of …

Cardiomyopathy frequently complicates sepsis and is associated with increased mortality.
Increased cardiac oxidative stress and mitochondrial dysfunction have been observed …

There is current awareness about the central role of mitochondrial dysfunction in the
development of cardiac dysfunction in systemic inflammatory syndromes, especially in …

Objective This study was designed to determine the role, if any, of the mitochondrial
permeability transition in the pathogenesis of mitochondrial injury in a representative …

The aim of this study was to determine whether mitochondrial nitric oxide (NO) synthase
(NOS) is involved in septic shock myocardial depression. The cecal ligation and puncture …