[HTML][HTML] ECM1 modified HF-MSCs targeting HSC attenuate liver cirrhosis by inhibiting the TGF-β/Smad signaling pathway

Q Liu, C Lv, Q Huang, L Zhao, X Sun, D Ning… - Cell Death …, 2022 - nature.com
Hair follicle-derived mesenchymal stem cells (HF-MSCs) show considerable therapeutic
potential for liver cirrhosis (LC). To improve the effectiveness of naïve HF-MSC treatments on …

[HTML][HTML] From hair to liver: Emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling …

Q Liu, C Lv, Y Jiang, K Luo, Y Gao, J Liu, X Zhang… - PeerJ, 2022 - peerj.com
Liver cirrhosis (LC) involves multiple systems throughout the body, and patients with LC
often die of multiple organ failure. However, few drugs are useful to treat LC. Hair follicle …

[HTML][HTML] BMSCs alleviate liver cirrhosis by regulating Fstl1/Wnt/β-Catenin signaling pathway

H Zhangdi, X Geng, N Li, R Xu, Y Hu, J Liu, X Zhang… - Heliyon, 2023 - cell.com
Researchers have shown that bone mesenchymal stem cells (BMSCs) can alleviate the
progression of liver cirrhosis; however, it is unclear how exactly BMSCs function to cure liver …

Human umbilical cord-derived mesenchymal stromal cells alleviate liver cirrhosis through the Hippo/YAP/Id1 pathway and macrophage-dependent mechanism

L Yao, X Hu, M Yuan, P Liu, Q Zhang, Z Wang… - International …, 2023 - Elsevier
Background Few effective anti-fibrotic therapies are currently available for liver cirrhosis.
Mesenchymal stromal cells (MSCs) ameliorate liver fibrosis and contribute to liver …

[HTML][HTML] The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis

X Yao, J Wang, J Zhu, X Rong - Stem Cell Research & Therapy, 2020 - Springer
Background Liver fibrosis resulting from chronic liver injury is one of the major causes of
mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the …

A simple and efficient strategy for cell‐based and cell‐free‐based therapies in acute liver failure: hUCMSCs bioartificial liver

L Feng, Y Wang, Y Fu, A Yimamu, Z Guo… - Bioengineering & …, 2023 - Wiley Online Library
Acute liver failure (ALF) is a life‐threatening condition. Cell‐based and cell‐free‐based
therapies have proven to be effective in treating ALF; however, their clinical application is …

[HTML][HTML] Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively

B Huang, X Cheng, H Wang, W Huang… - Journal of translational …, 2016 - Springer
Background Orthotopic liver transplantation is the only effective treatment for liver failure but
limited with shortage of available donor organs. Recent studies show promising results of …

[HTML][HTML] Human umbilical cord mesenchymal stem cells inhibit liver fibrosis via the microRNA-148a-5p/SLIT3 axis

M Yuan, L Yao, P Chen, Z Wang, P Liu, Z Xiong… - International …, 2023 - Elsevier
Background Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have
garnered considerable attention as prospective modalities of treatment for liver fibrosis (LF) …

[HTML][HTML] Human umbilical cord-derived mesenchymal stem cells ameliorate liver fibrosis by improving mitochondrial function via Slc25a47-Sirt3 signaling pathway

P Chen, M Yuan, L Yao, Z Xiong, P Liu, Z Wang… - Biomedicine & …, 2024 - Elsevier
Chronic Liver fibrosis may progress to liver cirrhosis and hepatocellular carcinoma (HCC),
hence cause a substantial global burden. However, effective therapies for blocking fibrosis …

Mechanisms of Action of Mesenchymal Stem Cells in Metabolic‐Associated Fatty Liver Disease

S Yi, Q Cong, Y Zhu, Q Xu - Stem Cells International, 2023 - Wiley Online Library
Metabolic‐associated fatty liver disease (MAFLD) is currently the most common chronic liver
disease worldwide. However, its pathophysiological mechanism is complicated, and …