[HTML][HTML] Synthesis and bioactivities of marine pyran-isoindolone derivatives as potential antithrombotic agents

Y Wang, H Chen, R Sheng, Z Fu, J Fan, W Wu, Q Tu… - Marine Drugs, 2021 - mdpi.com
2, 5-Bis-[8-(4, 8-dimethyl-nona-3, 7-dienyl)-5, 7-dihydroxy-8-methyl-3-keto-1, 2, 7, 8-
teraahydro-6 H-pyran [a] isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran …

Identification and Fibrinolytic Evaluation of an Isoindolone Derivative Isolated from a Rare Marine Fungus Stachybotrys longispora FG216

G Wang, W Wu, Q Zhu, S Fu, X Wang… - Chinese Journal of …, 2015 - Wiley Online Library
An isoindolone derivative, Fungi fibrinolytic compound (R)‐2, 5‐bis ((2R, 3R)‐2‐((E)‐4, 8‐
dimethylnona‐3, 7‐dien‐1‐yl)‐3, 5‐dihydroxy‐2‐methyl‐7‐oxo‐3, 4, 7, 9‐tetrahydropyrano …

Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys longispora FG216

R Guo, Y Zhang, D Duan, Q Fu, X Zhang… - Chinese Journal of …, 2016 - Wiley Online Library
As a part of our continuing work to discover bioactive leading molecules from marine
microorganism, ethyl acetate fraction of organic extract of the train Stachybotrys longispora …

[HTML][HTML] Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds …

Y Yin, Q Fu, W Wu, M Cai, X Zhou, Y Zhang - Marine Drugs, 2017 - mdpi.com
Many fungi in the Stachybotrys genus can produce various isoindolinone derivatives. These
compounds are formed by a spontaneous reaction between a phthalic aldehyde precursor …

[HTML][HTML] A Novel Marine Pyran-Isoindolone Compound Enhances Fibrin Lysis Mediated by Single-Chain Urokinase-Type Plasminogen Activator

C Gao, S Tang, H Zhang, H Zhang, T Zhang, B Bao… - Marine Drugs, 2022 - mdpi.com
Fungi fibrinolytic compound 1 (FGFC1) is a rare pyran-isoindolone derivative with fibrinolytic
activity. The aim of this study was to further determine the effect of FGFC1 on fibrin clots lysis …

[HTML][HTML] Progress in isoindolone alkaloid derivatives from marine microorganism: Pharmacology, preparation, and mechanism

S Hang, H Chen, W Wu, S Wang, Y Fang, R Sheng… - Marine Drugs, 2022 - mdpi.com
Compound 1 (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi Starchbotrys
longispora FG216 and fungi Stachybotrys microspora IFO 30018, possessed diverse …

[HTML][HTML] Evaluation of marine diindolinonepyrane in vitro and in vivo: Permeability characterization in Caco-2 cells monolayer and pharmacokinetic properties in …

Z Ma, R Guo, J Elango, B Bao, W Wu - Marine Drugs, 2019 - mdpi.com
A marine fibrinolytic compound was studied for use in thrombolytic therapy. Firstly, the
absorption and transportation characteristics of 2, 5-BH PA (2, 5-BH PA: 2, 5-Bis-[8-(4, 8 …

[HTML][HTML] Marine-inspired bis-indoles possessing antiproliferative activity against breast cancer; design, synthesis, and biological evaluation

WM Eldehna, GS Hassan, ST Al-Rashood… - Marine Drugs, 2020 - mdpi.com
Diverse indoles and bis-indoles extracted from marine sources have been identified as
promising anticancer leads. Herein, we designed and synthesized novel bis-indole series …

[HTML][HTML] Synthesis of novel indole Schiff base compounds and their antifungal activities

C Wang, L Fan, Z Pan, S Fan, L Shi, X Li, J Zhao, L Wu… - Molecules, 2022 - mdpi.com
A series of novel indole Schiff base derivatives (2a–2t) containing a 1, 3, 4-thiadiazole
scaffold modified with a thioether group were synthesized, and their structures were …

[HTML][HTML] Spiculisporic Acids B–D, Three New γ-Butenolide Derivatives from a Sea Urchin-Derived Fungus Aspergillus sp. HDf2

R Wang, TM Liu, MH Shen, MQ Yang, QY Feng… - Molecules, 2012 - mdpi.com
Three new γ-butenolide derivatives 1–3, named spiculisporic acids B–D, were isolated from
the culture of Aspergillus sp. HDf2, a marine-derived fungus that resides in the sea urchin …