Cell‐surface interactions play a crucial role for biomaterial application in orthopaedics. It is
evident that not only the chemical composition of solid substances influence cellular …

Nanotopographical cues of bone implant surface has direct influences on various cell types
during the establishment of osseointegration, a prerequisite of implant bear-loading. Given …

Understanding the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the
analysis of the mechanism of osseointegration, a requirement of long-term orthopedic …

Polymeric medical devices widely used in orthopedic surgery play key roles in fracture
fixation and orthopedic implant design. Topographical modification and surface micro …

A current medical challenge is the replacement of tissue which can be thought of in terms of
bone tissue engineering approaches. The key problem in bone tissue engineering lies in …

Nanotechnology is the study, production and controlled manipulation of materials with a
grain size< 100 nm. At this level, the laws of classical mechanics fall away and those of …

Nanostructured surfaces feature promising biological properties on biomaterials attracting
large interest at basic research, implant industry development, and bioengineering …

Orthopedic implants are widely used for the treatment of bone defects caused by injury,
infection, tumor and congenital diseases. However, poor osseointegration and implant …

Bone is a nanocomposite material comprised of hierarchically arranged collagen fibrils,
hydroxyapatite and proteoglycans in the nanometer scale. Cells are accustomed to interact …

Previous studies have demonstrated increased functions of osteoblasts (bone-forming cells)
on nanophase compared to conventional ceramics (specifically, alumina, titania, and …