▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …

Cellular genomes are vulnerable to an array of DNA-damaging agents, of both endogenous
and environmental origin. Such damage occurs at a frequency too high to be compatible …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

Each day a cell must face a constant onslaught of DNA lesions. Although we tend to worry
most about environmental sources of DNA damage (eg, chemical agents, UV radiation …

The advent of gene targeting techniques has permitted the construction of specific genetic
deficiencies to evaluate the biological contribution (s) of an individual protein. Mice lacking a …

Our cells are constantly exposed to insults from endogenous and exogenous agents that
can introduce damage into our DNA and generate genomic instability. Many of these lesions …

DNA repair systems are essential for the maintenance of genome integrity. Consequently,
the disregulation of repair genes can be expected to be associated with significant …

DNA is subjected to several modifications, resulting from endogenous and exogenous
sources. The cell has developed a network of complementary DNA-repair mechanisms, and …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

The genomic integrity of all living organisms is constantly jeopardized by physical [eg
ultraviolet (UV) light, ionizing radiation] and chemical (eg environmental pollutants …