High folate, perturbed one-carbon metabolism and gestational diabetes mellitus

JM Williamson, AL Arthurs, MD Smith, CT Roberts… - Nutrients, 2022 - mdpi.com
Folate is a dietary micronutrient essential to one-carbon metabolism. The World Health
Organisation recommends folic acid (FA) supplementation pre-conception and in early …

Maternal folate nutrition and offspring health: evidence and current controversies

A Caffrey, H McNulty, RE Irwin, CP Walsh… - Proceedings of the …, 2019 - cambridge.org
Periconceptional folic acid (FA) is known to have a protective effect in the prevention of
neural tube defects (NTD), leading to global recommendations for FA supplementation …

Folic acid supplement intake in early pregnancy increases risk of gestational diabetes mellitus: evidence from a prospective cohort study

B Zhu, X Ge, K Huang, L Mao, S Yan, Y Xu… - Diabetes …, 2016 - Am Diabetes Assoc
Folic acid (FA) is well known for its preventive effect on neural tube defects, and
recommendations for FA supplement before and during pregnancy have been well …

[HTML][HTML] Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid …

MSQ Murphy, KA Muldoon, H Sheyholislami… - The American Journal of …, 2021 - Elsevier
Background Periconceptional folic acid (FA) supplementation is recommended to prevent
the occurrence of neural tube defects. Currently, most over-the-counter FA supplements in …

Folate dose and form during pregnancy may program maternal and fetal health and disease risk

E Pannia, R Hammoud, R Simonian, R Kubant… - Nutrition …, 2022 - academic.oup.com
The role of folate, in its synthetic and bioactive form, as an in utero modifier of metabolic
outcomes in mothers and offspring is examined in this review. During pregnancy, a …

Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification …

T Jankovic-Karasoulos, MD Smith, S Leemaqz… - Nutrients, 2023 - mdpi.com
Folic acid (FA) food fortification in Australia has resulted in a higher-than-expected intake of
FA during pregnancy. High FA intake is associated with increased insulin resistance and …

Influence of maternal folate status on human fetal growth parameters

EM van Uitert… - Molecular nutrition & …, 2013 - Wiley Online Library
Worldwide periconceptional folic acid supplement use is recommended to prevent neural
tube defects. This also stimulated research on maternal folate status in association with fetal …

[HTML][HTML] Contemporary issues surrounding folic acid fortification initiatives

JH Choi, Z Yates, M Veysey, YR Heo… - Preventive nutrition and …, 2014 - ncbi.nlm.nih.gov
The impact of folate on health and disease, particularly pregnancy complications and
congenital malformations, has been extensively studied. Mandatory folic acid fortification …

Epidemiology and (patho) physiology of folic acid supplement use in obese women before and during pregnancy

M van der Windt, S Schoenmakers, B van Rijn… - Nutrients, 2021 - mdpi.com
Preconception folic acid supplement use is a well-known method of primary prevention of
neural tube defects (NTDs). Obese women are at a higher risk for having a child with a NTD …

Folic acid supplementation in pregnancy: are there devils in the detail?

GC Burdge, KA Lillycrop - British Journal of Nutrition, 2012 - cambridge.org
Maternal folic acid (FA) supplementation is well recognised to protect against neural tube
defects. Folate is a critical cofactor in one-carbon metabolism involved in the epigenetic …