Since its initial discovery in a Drosophila mutagenesis screen, the Hedgehog pathway has
been revealed to be instrumental in the proper development of the vertebrate face …

The Hedgehog signalling pathway plays a fundamental role in orchestrating normal
craniofacial development in vertebrates. In particular, Sonic hedgehog (Shh) is produced in …

Craniofacial development consists of a highly complex sequence of the orchestrated growth
and fusion of facial processes. It is also known that craniofacial abnormalities can be …

Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

Abstract BACKGROUND The Hedgehog (Hh) pathway provides inductive signals critical for
developmental patterning of the brain and face. In humans and in animal models …

Craniofacial defects (CFD) are a significant healthcare problem worldwide. Understanding
both the morphogenetic movements which underpin normal facial development, as well as …

There is growing evidence that implicates a role for Sonic hedgehog (SHH) in
morphogenesis of the craniofacial complex. Mutations in human and murine SHH cause …

Facial abnormalities in human SHH mutants have implicated the Hedgehog (Hh) pathway in
craniofacial development, but early defects in mouse Shh mutants have precluded the …

Mutations in SHH and several other genes encoding components of the Hedgehog
signaling pathway have been associated with holoprosencephaly syndromes, with …

Signaling pathways that play a fundamental role during development are turning out to
underlie many disease states when misregulated. Here, we review some of the recent …