Background Caveolae proteins play diverse roles in cancer development and progression.
In prostate cancer, non‐caveolar caveolin‐1 (CAV1) promotes metastasis, while CAVIN1 …

Most prostate cancer (PCa)-related deaths are caused by progression to bone metastasis.
Recently, the importance of extracellular vesicles (EVs) in pre-metastatic niche formation …

Background Bone metastasis is the leading cause of mortality and reduced quality of life in
patients with metastatic prostate cancer (PCa). Long non-coding RNA activated by DNA …

MicroRNAs in small extracellular vesicle (sEV-miRNAs) have been widely investigated as
crucial regulated molecules secreted by tumor cells to communicate with surroundings. It is …

Emerging evidence suggests that extracellular vesicle (EV)–containing miRNAs mediate
intercellular communications in response to noxious stimuli. It remains unclear how a cell …

Expression of caveolin-1 is up-regulated in prostate cancer metastasis and is associated
with aggressive recurrence of the disease. Intriguingly, caveolin-1 is also secreted from …

Lipid uptake occurs through caveolae, plasma membrane invaginations formed by caveolins
(CAV) and caveolae-associated protein 1 (CAVIN1). Genetic alterations of CAV1N1 and …

Caveolin-1 has a complex role in prostate cancer and has been suggested to be a potential
biomarker and therapeutic target. As mature caveolin-1 resides in caveolae, invaginated …

Extracellular vesicles (EVs) play critical roles in regulating bone metastatic
microenvironment through mediating intercellular crosstalks. However, little is known about …

Bone metastasis represents one of the most deleterious clinical consequences arising in the
context of many solid tumors. Severe osteolysis results from tumor cell colonization of the …