The blood-brain barrier (BBB) is one of the most essential protection mechanisms in the
central nervous system (CNS). It selectively allows individual molecules such as small lipid …

The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

Drug delivery to the central nervous system (CNS) is one of the most challenging fields of
research and development for pharmaceutical and biotechnology products. A number of …

Most of the potential therapeutic agents capable to modulate the pathophysiology or treat
the neurological disorders and brain tumors are useless in the current modern and …

The development of drugs to treat disorders of the central nervous system (CNS) faces
difficulties in achieving penetration of a drug through the blood–brain barrier (BBB) and …

The blood–brain barrier (BBB) plays an irreplaceable role in protecting the central nervous
system (CNS) from bloodborne pathogens. However, the BBB complicates the treatment of …

Effective non-invasive treatment of neurological diseases is often limited by the poor access
of therapeutic agents into the central nervous system (CNS). The majority of drugs and …

A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis,
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …

The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …

Major central nervous system disorders represent a significant and worldwide public health
problem. In fact, the therapeutic success of many pharmaceuticals developed to treat central …