The Role of Noradrenergic Signaling in Vagus Nerve Stimulation Dependent Motor Cortical Plasticity

CT Tseng - 2023 - utd-ir.tdl.org
The combination of vagus nerve stimulation (VNS) and motor rehabilitation is being reported
as a promising therapy for enhancing motor function recovery after neural injuries. Recent …

[HTML][HTML] Local activation of α2 adrenergic receptors is required for vagus nerve stimulation induced motor cortical plasticity

CT Tseng, SJ Gaulding, CLE Dancel, CA Thorn - Scientific reports, 2021 - nature.com
Vagus nerve stimulation (VNS) paired with rehabilitation training is emerging as a potential
treatment for improving recovery of motor function following stroke. In rats, VNS paired with …

[HTML][HTML] Vagus nerve stimulation induced motor map plasticity does not require cortical dopamine

J Brougher, CA Sanchez, US Aziz, KF Gove… - Frontiers in …, 2021 - frontiersin.org
Background: Vagus nerve stimulation (VNS) paired with motor rehabilitation is an emerging
therapeutic strategy to enhance functional recovery after neural injuries such as stroke …

Reorganization of motor cortex by vagus nerve stimulation requires cholinergic innervation

DR Hulsey, SA Hays, N Khodaparast, A Ruiz, P Das… - Brain stimulation, 2016 - Elsevier
Background Vagus nerve stimulation (VNS) paired with forelimb training drives robust,
specific reorganization of movement representations in the motor cortex. The mechanisms …

[HTML][HTML] Vagus nerve stimulation promotes cortical reorganization and reduces task-dependent calorie intake in male and female rats

CT Tseng, J Brougher, SJ Gaulding, BS Hassan… - Brain Research, 2020 - Elsevier
Numerous preclinical studies demonstrate that vagus nerve stimulation (VNS) paired with
motor rehabilitation improves functional recovery after neural injuries such as stroke …

[HTML][HTML] Common cholinergic, noradrenergic, and serotonergic drugs do not block VNS-mediated plasticity

RA Morrison, ST Abe, T Danaphongse… - Frontiers in …, 2022 - frontiersin.org
Vagus nerve stimulation (VNS) delivered during motor rehabilitation enhances recovery
from a wide array of neurological injuries and was recently approved by the US FDA for …

Vagus Nerve Stimulation Intensity Regulates Targeted Plasticity

RA Morrison - 2021 - utd-ir.tdl.org
Vagus nerve stimulation (VNS) paired with motor rehabilitation enhances recovery of
function after neurological injury in rats and humans. This effect is ascribed to VNS …

Brain plasticity and vagus nerve stimulation

M Keute, A Gharabaghi - Autonomic Neuroscience, 2021 - Elsevier
After damage to the central nervous system, caused by traumatic injury or ischemia,
plasticity becomes critically important for functional recovery. When this inherent capacity to …

Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

DR Hulsey, CM Shedd, SF Sarker, MP Kilgard… - Experimental …, 2019 - Elsevier
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific
reorganization of movement representations in the motor cortex. This effect is hypothesized …

[HTML][HTML] Enhancing rehabilitative therapies with vagus nerve stimulation

SA Hays - Neurotherapeutics, 2016 - Elsevier
Pathological neural activity could be treated by directing specific plasticity to renormalize
circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit …