Tau PET imaging in neurodegenerative disorders
C Groot, S Villeneuve, R Smith… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The advent of PET ligands that bind tau pathology has enabled the quantification and
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …
The development and validation of tau PET tracers: current status and future directions
N Okamura, R Harada, A Ishiki, A Kikuchi… - Clinical and translational …, 2018 - Springer
Purpose To provide an overview on positron emission tomography (PET) imaging of tau
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …
Overview of tau PET molecular imaging
GC Petersen, M Roytman, GC Chiang… - Current opinion in …, 2022 - journals.lww.com
Overview of tau PET molecular imaging : Current Opinion in Neurology Overview of tau PET
molecular imaging : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …
molecular imaging : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …
Direct comparison of the tau PET tracers 18F-flortaucipir and 18F-MK-6240 in human subjects
A Gogola, DS Minhas, VL Villemagne… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Tau PET tracers exhibit varying levels of specific signal and distinct off-target binding
patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently …
patterns that are more diverse than amyloid PET tracers. This study compared 2 frequently …
Tau PET imaging: present and future directions
Abnormal aggregation of tau in the brain is a major contributing factor in various
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …
neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of …
Tau imaging in neurodegenerative diseases
Aggregated tau protein is a major neuropathological substrate central to the
pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD) …
pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD) …
In vivo tau PET imaging in dementia: pathophysiology, radiotracer quantification, and a systematic review of clinical findings
In addition to the deposition of β-amyloid plaques, neurofibrillary tangles composed of
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's …
aggregated hyperphosphorylated tau are one of the pathological hallmarks of Alzheimer's …
Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
Purpose In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is
critical for early diagnosis and disease monitoring of Alzheimer's disease (AD). Methods …
critical for early diagnosis and disease monitoring of Alzheimer's disease (AD). Methods …
Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease
A next generation of tau PET tracers for the imaging of Alzheimer's disease and other
dementias has recently been developed. Whilst the new compounds have now entered …
dementias has recently been developed. Whilst the new compounds have now entered …
Tau PET imaging with 18F-PI-2620 in patients with Alzheimer disease and healthy controls: a first-in-humans study
A Mueller, S Bullich, O Barret, J Madonia… - Journal of Nuclear …, 2020 - Soc Nuclear Med
18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18F …
feature of Alzheimer disease (AD) and other neurodegenerative disorders. Preclinically, 18F …