Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine
Cardiotonic pills are a type of cardiovascular herbal medicine. To identify suitable
pharmacokinetic (PK) marker (s) for indicating systemic exposure to cardiotonic pills, we …
pharmacokinetic (PK) marker (s) for indicating systemic exposure to cardiotonic pills, we …
[PDF][PDF] High-performance liquid chromatographic determination of tanshinones in the roots of Salvia miltiorrhiza and related traditional Chinese medicinal preparations
AH Liu, YH Lin, M Yang, JH Sun, H Guo… - cardiovascular …, 2006 - researchgate.net
Purpose: This paper describes a validated high-performance liquid chromatographic
method to quantitate four tanshinones as markers; dihydrotanshinone I, cryptotanshinone …
method to quantitate four tanshinones as markers; dihydrotanshinone I, cryptotanshinone …
Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers
L Xing, ZR Tan, JL Cheng, WH Huang, W Zhang… - Scientific Reports, 2017 - nature.com
Salvia miltiorrhiza (SM) is widely used to treat microcirculatory disturbance-related diseases;
its lipophilic components play important roles in this application. Cryptotanshinone (CTS) …
its lipophilic components play important roles in this application. Cryptotanshinone (CTS) …
Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb‐Drug Interactions
Salvia miltiorrhiza root (Danshen) is widely used in Asia for its cardiovascular benefits and
contains both hydrophilic phenolic acids and lipophilic tanshinones, which are believed to …
contains both hydrophilic phenolic acids and lipophilic tanshinones, which are believed to …
Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure …
D Wang, W Yu, L Cao, C Xu, G Tan… - … & Drug Disposition, 2020 - Wiley Online Library
Salvia miltiorrhiza is one of the most commonly used traditional Chinese medicines in the
treatment of cardiovascular and cerebrovascular diseases. Cryptotanshinone (CTS) …
treatment of cardiovascular and cerebrovascular diseases. Cryptotanshinone (CTS) …
Systemic exposure to and disposition of catechols derived from Salvia miltiorrhiza roots (Danshen) after intravenous dosing DanHong injection in human subjects, rats …
M Li, F Wang, Y Huang, F Du, C Zhong… - Drug Metabolism and …, 2015 - ASPET
DanHong injection is a Danshen (Salvia miltiorrhiza roots)-based injectable solution for
treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed …
treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed …
Renal tubular secretion of tanshinol: molecular mechanisms, impact on its systemic exposure, and propensity for dose-related nephrotoxicity and for renal herb-drug …
W Jia, F Du, X Liu, R Jiang, F Xu, J Yang, L Li… - Drug Metabolism and …, 2015 - ASPET
Tanshinol has desirable antianginal and pharmacokinetic properties and is a key compound
of Salvia miltiorrhiza roots (Danshen). It is extensively cleared by renal excretion. This study …
of Salvia miltiorrhiza roots (Danshen). It is extensively cleared by renal excretion. This study …
Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of …
HC Bi, Z Zuo, X Chen, CS Xu, YY Wen, HY Sun… - Xenobiotica, 2008 - Taylor & Francis
Tanshinone IIA (TSIIA) is a major active triterpenoid isolated from Salvia miltiorrhiza. The
purposes of this study were to investigate various preclinical factors that determined the …
purposes of this study were to investigate various preclinical factors that determined the …
Metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in rats
Y Zhang, P Shi, H Yao, Q Shao… - Current drug metabolism, 2012 - ingentaconnect.com
Qishen yiqi pills (QY pills) are a type of standardized cardiovascular herbal medicine, which
contain four component herbs, ie, Astragalus membranaceus (Huangqi), Salvia miltiorrhiza …
contain four component herbs, ie, Astragalus membranaceus (Huangqi), Salvia miltiorrhiza …
Tanshinone IIA: a promising natural cardioprotective agent
Q Shang, H Xu, L Huang - Evidence‐Based Complementary …, 2012 - Wiley Online Library
Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the
root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring …
root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring …